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- W4313374586 abstract "Abstract Severe fever with thrombocytopenia syndrome (SFTS) is an emerging hemorrhagic fever with a high mortality rate in humans, which is caused by SFTS virus (SFTSV), a novel phlebovirus in the Bunyaviridae family, is tick borne and is endemic in Eastern Asia. Previous study found that SFTSV can infect and replicate in macrophages in vivo and in vitro. However, the role of macrophages in virus replication and the potential pathogenic mechanisms of SFTSV in macrophage remain unclear. In this study, we provided evidence that the SFTSV infection drove macrophage differentiation skewed to M2 phenotype, facilitated virus shedding and resulted in viral spread. We showed evidence that miR-146a and b were significantly upregulated in macrophages during the SFTSV infection, driving the differentiation of macrophages into M2 cells by targeting STAT1. Further analysis revealed that the elevated miR-146b but not miR-146a was responsible for IL-10 stimulation. We also found that SFTSV increased endogenous miR-146b-induced differentiation of macrophages into M2 cells mediated by viral non-structural protein (NSs). The M2 skewed differentiation of macrophages may have important implication to the pathogenesis of SFTS. Myeloid cell populations are influenced in patients’ peripheral blood during acute SFTS virus infection. SFTSV specifically targets human CD14+ blood monocytes, inducing phenotypic shift. Our studies imply that monocytes/macrophages may support persistent SFTSV viral infection. However, the evidence that monocytes/macrophages are directly involved in the development of SFTS in patients, particularly those in the acute phase." @default.
- W4313374586 created "2023-01-06" @default.
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- W4313374586 date "2020-05-01" @default.
- W4313374586 modified "2023-10-16" @default.
- W4313374586 title "Severe fever with thrombocytopenia syndrome (SFTS) induce innate immunity disorder particularly in monocyte subsets" @default.
- W4313374586 doi "https://doi.org/10.4049/jimmunol.204.supp.248.10" @default.
- W4313374586 hasPublicationYear "2020" @default.
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