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- W4313374592 abstract "Abstract Recent reports from the breast cancer (BrCa) suggests that >90% of patients diagnosed at an early stage are successfully treated with surgery, chemotherapy, and radiation or combination. However, chemoresistance, recurrence and metastasis have been noticed in advanced BrCa patients and still remains a challenge. Chemokine receptor-ligand interaction has been noticed to play a significant role in homing to cancer cells to distant sites. Fractalkine (CX3CL1), a structurally distinct chemokine, and its receptor (CX3CR1), are expressed in majority of the cancer including BrCa. Thus, therapeutic strategies that inhibit tumor immune microenvironment of BrCa cells can improve the quality life of patients. In this study, we analyzed the expression and role of the CX3CR1/CX3CL1 axis interface in the progression and invasiveness of BrCa. In vitro investigation of BrCa cell lines MCF-7 and MDA-MB-231 showed higher expression of CX3CR1 analyzed through flow cytometry, RT-PCR, western blot, and immunofluorescence techniques. This was corroborated by our clinical tissue microarray results that showed significantly (p < 0.001) higher expression of CX3CR1 and CX3CL1 in cancerous tissues compared to normal tissues. Furthermore, treatment of BrCa cells with small molecule antagonist JMS-17-2 abrogated the proliferation and metastasis of cancer cells delineating the role CX3CR1-CX3CL1 chemotaxis mediated metastasis of BrCa. This data demonstrates, both biological and clinical significance of CX3CR1 and CX3CL1 expression that may contribute to BrCa metastasis. Inhibition of CX3CR1/CX3CL1 interaction thus could be a promising avenue for researchers to target or treat BrCa." @default.
- W4313374592 created "2023-01-06" @default.
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- W4313374592 date "2020-05-01" @default.
- W4313374592 modified "2023-09-27" @default.
- W4313374592 title "CX3CR1/CX3CL1 axis in breast cancer pathology and its therapeutic use" @default.
- W4313374592 doi "https://doi.org/10.4049/jimmunol.204.supp.59.2" @default.
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