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- W4313374617 startingPage "70.11" @default.
- W4313374617 abstract "Abstract Influenza A Virus (IAV) is the virus responsible for the flu and affects 3 to 5 million people around the world. Although vaccines exist for common strains of IAV, whenever pandemic strains of IAV arise humans are largely unprotected. Thus, new treatment strategies are required for pandemic strains of IAV as well as serious cases of IAV infection that can result in a bacterial superinfection. Treatments that reduce viral load in an infected host would be optimal to reduce virus spread as well as to potentially alleviate viral burden on the host. Mammals have many host defense peptides such defensins, lectins and cathelicidins. Cathelicidins are short cationic peptides that are antimicrobial in nature, and have been shown to have anti-IAV properties along with other antimicrobial functions. A critical domain of LL-37, the only human cathelicidin, has been shown to have a central helix with a hydrophobic surface. This critical domain is the minimum sequence of LL-37 required to have antimicrobial properties. There is no consensus on the mechanism LL-37 utilizes to neutralize bacteria and viruses. However, we hypothesize that by mutating single hydrophobic residues in the critical domain to a hydrophilic residue we can see changes in LL-37 neutralization of various IAV strains. Using fluorescent focus assays, we can quantify IAV titers after exposure to LL-37 and other cationic peptides. Here we show that reducing the hydrophobic residues within the critical domain of LL-37 reduces seasonal and pandemic IAV titers in vitro. These results lend credence to the theory of the hydrophobic surface of LL-37 is responsible for its anti-IAV effects." @default.
- W4313374617 created "2023-01-06" @default.
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- W4313374617 date "2020-05-01" @default.
- W4313374617 modified "2023-09-27" @default.
- W4313374617 title "Mutations in the critical domain of human cathelicidin LL-37 affect neutralization of IAV" @default.
- W4313374617 doi "https://doi.org/10.4049/jimmunol.204.supp.70.11" @default.
- W4313374617 hasPublicationYear "2020" @default.
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