Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313374672> ?p ?o ?g. }
Showing items 1 to 78 of
78
with 100 items per page.
- W4313374672 endingPage "73.4" @default.
- W4313374672 startingPage "73.4" @default.
- W4313374672 abstract "Abstract Pregnant women undergo dynamic metabolic and immunologic changes to ensure provision of nutrients to, and prevent rejection of, the fetus. The mother increases glucose production, glucose intolerance and insulin resistance to support fetal-placental development and transitions from lipid storage to lipolysis to meet her own energy demands. Maternal immunoregulation prevents rejection of the fetal semi-allograft whilst maintaining protection against pathogens. Hypothesis Immunometabolic adaptation underpins maternal immune function changes in pregnancy. Aim To determine whether monocytes undergo metabolic adaptation in pregnancy and at which gestational stage this might occur. Results Peripheral blood monocytes of term pregnant (>37 weeks) and not pregnant women were compared using flow cytometry. Pregnant women had significantly more non-classical CD16+ monocytes, and CD16+ and CD16− subsets had more CD36 (fatty acid transporter; p = 0.0025) and less CD98 (amino acid transporter; p = 0.0043). Bioenergetic analysis of monocytes showed oxidative phosphorylation was significantly reduced in pregnant women; glycolysis was unchanged. Also, oxidative phosphorylation was reduced significantly in the mononuclear cells of women with gestational diabetes at 28 weeks compared to healthy pregnant women at the same gestational stage. Discussion Ongoing work includes analysis of mitochondrial health and measuring transcriptomics, biosynthetic lipids, cytokines, and enzyme responses. Results are vital to understanding immunological adaptation during pregnancy. This could provide insight into adverse pregnancy outcomes and women’s long-term health in relation to immune-mediated diseases." @default.
- W4313374672 created "2023-01-06" @default.
- W4313374672 creator A5002389788 @default.
- W4313374672 creator A5020862368 @default.
- W4313374672 creator A5021607726 @default.
- W4313374672 creator A5030051084 @default.
- W4313374672 creator A5034976125 @default.
- W4313374672 creator A5069591406 @default.
- W4313374672 date "2020-05-01" @default.
- W4313374672 modified "2023-09-27" @default.
- W4313374672 title "Maternal immunometabolic adaptation in pregnancy" @default.
- W4313374672 doi "https://doi.org/10.4049/jimmunol.204.supp.73.4" @default.
- W4313374672 hasPublicationYear "2020" @default.
- W4313374672 type Work @default.
- W4313374672 citedByCount "0" @default.
- W4313374672 crossrefType "journal-article" @default.
- W4313374672 hasAuthorship W4313374672A5002389788 @default.
- W4313374672 hasAuthorship W4313374672A5020862368 @default.
- W4313374672 hasAuthorship W4313374672A5021607726 @default.
- W4313374672 hasAuthorship W4313374672A5030051084 @default.
- W4313374672 hasAuthorship W4313374672A5034976125 @default.
- W4313374672 hasAuthorship W4313374672A5069591406 @default.
- W4313374672 hasConcept C126322002 @default.
- W4313374672 hasConcept C134018914 @default.
- W4313374672 hasConcept C170493617 @default.
- W4313374672 hasConcept C172680121 @default.
- W4313374672 hasConcept C203014093 @default.
- W4313374672 hasConcept C2776953305 @default.
- W4313374672 hasConcept C2777391703 @default.
- W4313374672 hasConcept C2779234561 @default.
- W4313374672 hasConcept C2779434492 @default.
- W4313374672 hasConcept C2779828298 @default.
- W4313374672 hasConcept C46973012 @default.
- W4313374672 hasConcept C54355233 @default.
- W4313374672 hasConcept C55493867 @default.
- W4313374672 hasConcept C555293320 @default.
- W4313374672 hasConcept C57600042 @default.
- W4313374672 hasConcept C71924100 @default.
- W4313374672 hasConcept C86803240 @default.
- W4313374672 hasConcept C8891405 @default.
- W4313374672 hasConceptScore W4313374672C126322002 @default.
- W4313374672 hasConceptScore W4313374672C134018914 @default.
- W4313374672 hasConceptScore W4313374672C170493617 @default.
- W4313374672 hasConceptScore W4313374672C172680121 @default.
- W4313374672 hasConceptScore W4313374672C203014093 @default.
- W4313374672 hasConceptScore W4313374672C2776953305 @default.
- W4313374672 hasConceptScore W4313374672C2777391703 @default.
- W4313374672 hasConceptScore W4313374672C2779234561 @default.
- W4313374672 hasConceptScore W4313374672C2779434492 @default.
- W4313374672 hasConceptScore W4313374672C2779828298 @default.
- W4313374672 hasConceptScore W4313374672C46973012 @default.
- W4313374672 hasConceptScore W4313374672C54355233 @default.
- W4313374672 hasConceptScore W4313374672C55493867 @default.
- W4313374672 hasConceptScore W4313374672C555293320 @default.
- W4313374672 hasConceptScore W4313374672C57600042 @default.
- W4313374672 hasConceptScore W4313374672C71924100 @default.
- W4313374672 hasConceptScore W4313374672C86803240 @default.
- W4313374672 hasConceptScore W4313374672C8891405 @default.
- W4313374672 hasIssue "1_Supplement" @default.
- W4313374672 hasLocation W43133746721 @default.
- W4313374672 hasOpenAccess W4313374672 @default.
- W4313374672 hasPrimaryLocation W43133746721 @default.
- W4313374672 hasRelatedWork W1993795923 @default.
- W4313374672 hasRelatedWork W2039466440 @default.
- W4313374672 hasRelatedWork W2045448786 @default.
- W4313374672 hasRelatedWork W2078493089 @default.
- W4313374672 hasRelatedWork W2095329316 @default.
- W4313374672 hasRelatedWork W2099734673 @default.
- W4313374672 hasRelatedWork W2131811784 @default.
- W4313374672 hasRelatedWork W2148383459 @default.
- W4313374672 hasRelatedWork W2397705441 @default.
- W4313374672 hasRelatedWork W4293597390 @default.
- W4313374672 hasVolume "204" @default.
- W4313374672 isParatext "false" @default.
- W4313374672 isRetracted "false" @default.
- W4313374672 workType "article" @default.