Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313374736> ?p ?o ?g. }
Showing items 1 to 62 of
62
with 100 items per page.
- W4313374736 endingPage "79.21" @default.
- W4313374736 startingPage "79.21" @default.
- W4313374736 abstract "Abstract STING is an endoplasmic reticulum (ER)-associated transmembrane protein that is essential for the host innate immune response to pathogens. STING is activated by the second messenger cyclic dinucleotides which is produced from the invading pathogen or by the host DNA sensor cGAS. Activation of STING triggers its trafficking from the ER, through ERGIC/Golgi, to vesicles, during which time STING activates and quickly terminates downstream interferon signaling. Despite the importance of STING signaling in infection, autoimmune disease and cancer immunotherapy, the dynamics of STING trafficking and kinetics of signaling are poorly understood. Here, we performed a time-resolved proteomic screen to capture protein interaction networks of STING during its trafficking process. We also established a synchronized live-cell microscopy technique that allows us to define changes in protein trafficking kinetics. We have identified several co-factor candidates that affect various steps of the STING trafficking and signaling. Collectively, our findings revealed the previously unanticipated the regulation of STING trafficking as well as its downstream signaling by the host factors in the secretory pathway." @default.
- W4313374736 created "2023-01-06" @default.
- W4313374736 creator A5004247510 @default.
- W4313374736 creator A5022376467 @default.
- W4313374736 creator A5051035933 @default.
- W4313374736 date "2020-05-01" @default.
- W4313374736 modified "2023-09-26" @default.
- W4313374736 title "Regulation of STING Trafficking and Interferon Response" @default.
- W4313374736 doi "https://doi.org/10.4049/jimmunol.204.supp.79.21" @default.
- W4313374736 hasPublicationYear "2020" @default.
- W4313374736 type Work @default.
- W4313374736 citedByCount "0" @default.
- W4313374736 crossrefType "journal-article" @default.
- W4313374736 hasAuthorship W4313374736A5004247510 @default.
- W4313374736 hasAuthorship W4313374736A5022376467 @default.
- W4313374736 hasAuthorship W4313374736A5051035933 @default.
- W4313374736 hasConcept C119062480 @default.
- W4313374736 hasConcept C127413603 @default.
- W4313374736 hasConcept C136449434 @default.
- W4313374736 hasConcept C146978453 @default.
- W4313374736 hasConcept C158617107 @default.
- W4313374736 hasConcept C203014093 @default.
- W4313374736 hasConcept C2776178377 @default.
- W4313374736 hasConcept C2777349159 @default.
- W4313374736 hasConcept C2779300339 @default.
- W4313374736 hasConcept C62478195 @default.
- W4313374736 hasConcept C86803240 @default.
- W4313374736 hasConcept C8891405 @default.
- W4313374736 hasConcept C95444343 @default.
- W4313374736 hasConceptScore W4313374736C119062480 @default.
- W4313374736 hasConceptScore W4313374736C127413603 @default.
- W4313374736 hasConceptScore W4313374736C136449434 @default.
- W4313374736 hasConceptScore W4313374736C146978453 @default.
- W4313374736 hasConceptScore W4313374736C158617107 @default.
- W4313374736 hasConceptScore W4313374736C203014093 @default.
- W4313374736 hasConceptScore W4313374736C2776178377 @default.
- W4313374736 hasConceptScore W4313374736C2777349159 @default.
- W4313374736 hasConceptScore W4313374736C2779300339 @default.
- W4313374736 hasConceptScore W4313374736C62478195 @default.
- W4313374736 hasConceptScore W4313374736C86803240 @default.
- W4313374736 hasConceptScore W4313374736C8891405 @default.
- W4313374736 hasConceptScore W4313374736C95444343 @default.
- W4313374736 hasIssue "1_Supplement" @default.
- W4313374736 hasLocation W43133747361 @default.
- W4313374736 hasOpenAccess W4313374736 @default.
- W4313374736 hasPrimaryLocation W43133747361 @default.
- W4313374736 hasRelatedWork W2261136487 @default.
- W4313374736 hasRelatedWork W2295001336 @default.
- W4313374736 hasRelatedWork W2335081293 @default.
- W4313374736 hasRelatedWork W2365048626 @default.
- W4313374736 hasRelatedWork W2966597045 @default.
- W4313374736 hasRelatedWork W3123341980 @default.
- W4313374736 hasRelatedWork W3211967361 @default.
- W4313374736 hasRelatedWork W4285012919 @default.
- W4313374736 hasRelatedWork W4311936082 @default.
- W4313374736 hasRelatedWork W4312084899 @default.
- W4313374736 hasVolume "204" @default.
- W4313374736 isParatext "false" @default.
- W4313374736 isRetracted "false" @default.
- W4313374736 workType "article" @default.