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- W4313374889 abstract "Lichen planopilaris (LPP) is a type of cicatricial alopecia that results in permanent hair loss commonly occurring in Caucasian and Indian women. LPP is considered a subtype of lichen planus whose characteristic skin findings may or may not be observed in patients diagnosed with LPP. There are several subtypes of LPP including classic, frontal fibrosing, and Graham-Little-Piccardi-Lasseur, each of which targets different areas of the body. The classic type usually occurs on the vertex and parietal scalp while frontal fibrosing alopecia targets the frontotemporal scalp. Graham-Little-Piccardi-Lasseur subtype presents with a cicatricial spreading pattern. The pathogenesis of LPP is not well understood, though there are several proposed mechanisms. One possible mechanism involves the upregulation of cell-mediated immunity pathways which lead to the targeting of follicular antigens and thus the permanent hair loss that can occur. Other affected pathways include upregulation of JAK expression which also results in the upregulation of proinflammatory cytokines and thus the destruction of the hair follicles. Treatment involves halting the scarring hair loss process before it occurs. First-line treatments typically include topical and intralesional corticosteroids. Novel treatments, based primarily on case studies, which target some of the primary pathogenic pathways include pioglitazone and tofacitinib. Treatment expectations should be discussed with patients before initiation as regrowth of previously destroyed hair follicles may not be possible. It is also important to consider the effect of LPP on patients’ mental health as this may affect the treatment goals and plan." @default.
- W4313374889 created "2023-01-06" @default.
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- W4313374889 date "2022-01-01" @default.
- W4313374889 modified "2023-10-16" @default.
- W4313374889 title "66-Year-Old Female with Itchy Scalp and Hair Loss" @default.
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- W4313374889 doi "https://doi.org/10.1007/978-3-031-15820-9_10" @default.
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