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- W4313375610 abstract "Summary The soluble antigen (S) of the commercial typhus vaccine has been concentrated by a variety of methods. Sedimentation in an ultracentrifuge at 90,000 G for 40 minutes has resulted in the isolation of a considerably purified S in good yield, possessing both the epidemic and murine complement-fixing activities of the original vaccine. Alcohol and salt precipitation were not successful in effecting a purification of S or in preserving the solubility of this material. Two isolation methods, based on a prior knowledge of the chemically reactive carbonyl groups of S, were successful in the concentration and purification of S in an active antigenic state, although the power to fix murine antibody in the complement-fixing reaction was frequently lost. The product obtained as a result of treatment with phenylhydrazine-p-sulfonic acid, although still impure, was soluble after lyophilization. This material, as well as the far purer material precipitated with Na2SO3, represents a concentrated antigen solution potentially adaptable for numerous practical ends." @default.
- W4313375610 created "2023-01-06" @default.
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- W4313375610 date "1950-11-01" @default.
- W4313375610 modified "2023-09-23" @default.
- W4313375610 title "Studies on Commercial Typhus Vaccines" @default.
- W4313375610 doi "https://doi.org/10.4049/jimmunol.65.5.465" @default.
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