Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313376051> ?p ?o ?g. }
Showing items 1 to 49 of
49
with 100 items per page.
- W4313376051 endingPage "309" @default.
- W4313376051 startingPage "302" @default.
- W4313376051 abstract "Summary and Conclusions These studies emphasize the exacting conditions required for demonstration of endotoxin-induced resistance to typhoid infection. The degree of protection is never very great and can be readily overcome by increasing the challenge dose. It is also dependent upon the routes of inoculation and the interval of time between protective and challenge injections. Enhanced resistance to peritoneal typhoid infection was most marked in mice previously injected intraperitoneally with endotoxin. The incidence of death from cerebral typhoid infection was only slightly affected by intravenous or intraperitoneal injection of endotoxin, and not at all by subcutaneous injection. However, striking protection against cerebral typhoid infection was noted in mice pretreated with endotoxin by the intracerebral route. These observations suggest that local alterations of tissue susceptibility occur at the site of injection of endotoxin. The significance of these findings is discussed in the following paper on resistance to virus neurotoxicity. An advantage accruing to the use of the brain as the site of infection is the relative ease with which reproducible growth curves of typhoid bacilli could be obtained. In support of the findings of Landy and Pillemer on typhoid peritonitis, the bacterial titers in the brains of resistant mice were appreciably lower than those in fully susceptible controls. Despite the favorable outcome of infection in mice pretreated with endotoxin, typhoid bacilli persisted at relatively high and constant levels throughout an observation period of 10 days. Refractoriness to cerebral typhoid infection induced by prior injection of typhoid vaccine or xerosin is almost undoubtedly related to the endotoxin present in these materials. In contrast to its antiviral action, xerosin was the least effective of the products derived from Gram-negative bacteria. Slightly increased resistance to cerebral typhoid infections could also be demonstrated by pretreatment with influenza virus. The results with staphylococcus vaccine were uncertain and the inflammatory response produced by intracerebral injection of aleuronat was not accompanied by protection aginst typhoid infection. Intracerebral injection of endotoxin or typhoid vaccine did not alter susceptibility to cerebral infection with streptococci or pneumococci. The capacity of bacterial products to bolster host resistance appears to be demonstrated most easily in infections with Gram-negative bacteria and, as will be shown in the following report, to the toxic action of viruses." @default.
- W4313376051 created "2023-01-06" @default.
- W4313376051 creator A5056207479 @default.
- W4313376051 creator A5059367411 @default.
- W4313376051 date "1959-09-01" @default.
- W4313376051 modified "2023-09-23" @default.
- W4313376051 title "The Resistance-Promoting Activity of Endotoxins and Other Microbial Products" @default.
- W4313376051 doi "https://doi.org/10.4049/jimmunol.83.3.302" @default.
- W4313376051 hasPublicationYear "1959" @default.
- W4313376051 type Work @default.
- W4313376051 citedByCount "3" @default.
- W4313376051 crossrefType "journal-article" @default.
- W4313376051 hasAuthorship W4313376051A5056207479 @default.
- W4313376051 hasAuthorship W4313376051A5059367411 @default.
- W4313376051 hasBestOaLocation W43133760511 @default.
- W4313376051 hasConcept C159047783 @default.
- W4313376051 hasConcept C203014093 @default.
- W4313376051 hasConcept C520601542 @default.
- W4313376051 hasConcept C71924100 @default.
- W4313376051 hasConcept C86803240 @default.
- W4313376051 hasConcept C89423630 @default.
- W4313376051 hasConcept C98274493 @default.
- W4313376051 hasConceptScore W4313376051C159047783 @default.
- W4313376051 hasConceptScore W4313376051C203014093 @default.
- W4313376051 hasConceptScore W4313376051C520601542 @default.
- W4313376051 hasConceptScore W4313376051C71924100 @default.
- W4313376051 hasConceptScore W4313376051C86803240 @default.
- W4313376051 hasConceptScore W4313376051C89423630 @default.
- W4313376051 hasConceptScore W4313376051C98274493 @default.
- W4313376051 hasIssue "3" @default.
- W4313376051 hasLocation W43133760511 @default.
- W4313376051 hasOpenAccess W4313376051 @default.
- W4313376051 hasPrimaryLocation W43133760511 @default.
- W4313376051 hasRelatedWork W155301942 @default.
- W4313376051 hasRelatedWork W1997917641 @default.
- W4313376051 hasRelatedWork W2015852140 @default.
- W4313376051 hasRelatedWork W2406674412 @default.
- W4313376051 hasRelatedWork W2412549289 @default.
- W4313376051 hasRelatedWork W2423786332 @default.
- W4313376051 hasRelatedWork W2587877764 @default.
- W4313376051 hasRelatedWork W4244369537 @default.
- W4313376051 hasRelatedWork W97774765 @default.
- W4313376051 hasRelatedWork W180869716 @default.
- W4313376051 hasVolume "83" @default.
- W4313376051 isParatext "false" @default.
- W4313376051 isRetracted "false" @default.
- W4313376051 workType "article" @default.