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- W4313376068 abstract "Summary Mice actively sensitized to egg albumin responded to intradermal challenge with the antigen by the development of immediate-type hypersensitive reactions. Two separate reactions were distinguishable macroscopically and microscopically. Phase 1 reaction consisted of a rapid, transitory inflammation, in which there was evidence of mast cell degranulation. It occurred as the only reaction very early after sensitization, and was briefly noticeable in animals tested later after sensitization. Phase 2 reaction, which when fully developed was a typical Arthus reaction, appeared only in the mice tested at longer intervals after the sensitizing injection. In these animals it developed more slowly than the phase 1 reaction, but eventually obscured it. Phase 2, also, took the form of an acute inflammation, particularly characterized by the occurrence of perivascular cuffing by neutrophilic polymorphonuclear leukocytes. Mast cell degranulation was not a feature of phase 2." @default.
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- W4313376068 date "1963-11-01" @default.
- W4313376068 modified "2023-10-17" @default.
- W4313376068 title "Studies on Immediate Cutaneous Hypersensitivity in Mice" @default.
- W4313376068 doi "https://doi.org/10.4049/jimmunol.91.5.651" @default.
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