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- W4313376323 abstract "Summary Newborn C3H mice were rendered tolerant to CBA skin homografts by neonatal injection of CBA spleen cells. The offspring of these tolerant C3H mice were slightly more susceptible to a tolerance-inducing stimulus of CBA spleen cells than were the offspring of nontolerant C3H mice. The immunologic competence of normal C3H spleen and lymph node cells, as measured by the graft-versus-host assay in newborn C57BL/6J mice, continued to increase with age, exhibiting peaks of immunologic reactivity at 3 and 6 months for spleen, and at 7 months for lymph node cells. The increased immune potential of C3H mice with age could, at least in part, be responsible for the delayed loss of tolerance in C3H mice. The immunologic reactivity of C3H spleen and lymph node cells, during the various phases of tolerance, as measured by the graft-versus-host assay in newborn CBA mice, was subnormal but increased during graft contraction and graft rejection. The prolonged survival of second and third CBA skin grafts and the relative ease by which tolerance could be reinduced, were additional evidence for the subnormal immunologic status of post-tolerant C3H mice." @default.
- W4313376323 created "2023-01-06" @default.
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- W4313376323 date "1964-07-01" @default.
- W4313376323 modified "2023-09-27" @default.
- W4313376323 title "Acquired Tolerance to Skin Homografts in Mice" @default.
- W4313376323 doi "https://doi.org/10.4049/jimmunol.93.1.114" @default.
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