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- W4313376429 abstract "Summary The anti-viral effect of N-ethylisatin β-thiosemicarbazone was determined in mice infected i.c. with vaccinia virus. The findings indicated that a single dose of 4 mg given as early as 72 hours before infection produced a 1 to 2 log lower PFU and LD50 titer and 80 to 100% net survival. When drug was given after virus inoculation, anti-viral efficacy was related to dose and time of treatment. In general, elementary or inclusion bodies were not observed in the brains of surviving drug-treated mice, and inflammatory changes were not suppressed. The absence of antibody or interferon in the brains of drug-treated mice prior to the 10th day following infection showed that protection was solely due to the virostatic action of N-ethylisatin β-thiosemicarbazone." @default.
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- W4313376429 date "1965-05-01" @default.
- W4313376429 modified "2023-09-26" @default.
- W4313376429 title "Antiviral Activity of <i>N</i>-Ethylisatin β-Thiosemicarbazone in Vaccinia-Infected Mice" @default.
- W4313376429 doi "https://doi.org/10.4049/jimmunol.94.5.794" @default.
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