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- W4313376435 abstract "Summary Skin sensitizing capacities of five groups of mouse immunoglobulin were investigated. Mouse 7 S γ2-globulins were capable of sensitizing guinea pig (heterologous) skin for passive cutaneous anaphylaxis and reverse passive cutaneous anaphylaxis. No heterologous passive cutaneous anaphylaxis activity was present, however, in the 7 S γ1-globulin, β2A-globulin or γ1-macroglobulin classes. The heterologous skin sensitizing ability of the 7 S γ2-globulins was further investigated by examining two subclasses, 7 S γ2a-globulin and 7 S γ2b-globulin, with the aid of purified mouse myeloma proteins. Heterologous skin sensitizing activity was identified in the γ2a-globulin but not in the γ2b-globulin subclass. The presence or absence of heterologous skin sensitizing activity within the 7 S γ2-globulin class correlated with the presence or absence of allotypic isoantigens and with specific antigenic determinants detected by rabbit antiserum." @default.
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- W4313376435 date "1965-03-01" @default.
- W4313376435 modified "2023-10-16" @default.
- W4313376435 title "The Immunoglobulins of Mice" @default.
- W4313376435 doi "https://doi.org/10.4049/jimmunol.94.3.410" @default.
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