Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313376818> ?p ?o ?g. }
- W4313376818 endingPage "4739" @default.
- W4313376818 startingPage "4731" @default.
- W4313376818 abstract "Abstract The transcriptional activation of class II MHC genes requires the class II transactivator (CIITA) protein, a regulator that is essential for both constitutive and IFN-γ-inducible class II MHC expression. The CIITA gene is controlled by multiple independent promoters; two promoters direct constitutive expression, while another, the type IV CIITA promoter, mediates IFN-γ-induced expression. We investigated the molecular regulation of IFN-γ-induced type IV CIITA promoter activity in astrocytes. IFN-γ inducibility of the type IV CIITA promoter is dependent on three cis-acting elements contained within a 154-bp fragment of the promoter; the proximal IFN-γ activation sequence (GAS) element, the E box, and the proximal IFN regulatory factor (IRF) element. Two IFN-γ-activated transcription factors, STAT-1α and IRF-1, bind the proximal GAS and IRF elements, respectively. The E box binds upstream stimulating factor-1 (USF-1), a constitutively expressed transcription factor. Furthermore, STAT-1α binding to the proximal GAS element is dependent on the binding of USF-1 to the adjacent E box. Functionally, the proximal IRF element is essential for IFN-γ induction of type IV CIITA promoter activity, while the proximal GAS and E box elements contribute to the IFN-γ inducibility of this promoter. In astrocytes, TNF-α enhances IFN-γ-induced class II MHC transcription. Our results demonstrate that TNF-α does not enhance IFN-γ-induced transcriptional activation of the type IV CIITA promoter, indicating that the enhancing effect of TNF-α is mediated downstream of CIITA transcription. These results define the molecular basis of IFN-γ activation of the type IV CIITA promoter in astrocytes." @default.
- W4313376818 created "2023-01-06" @default.
- W4313376818 creator A5032172517 @default.
- W4313376818 creator A5032782967 @default.
- W4313376818 creator A5073371361 @default.
- W4313376818 date "1999-04-15" @default.
- W4313376818 modified "2023-10-11" @default.
- W4313376818 title "IFN-γ Regulation of the Type IV Class II Transactivator Promoter in Astrocytes" @default.
- W4313376818 cites W1489835711 @default.
- W4313376818 cites W1510347472 @default.
- W4313376818 cites W1511268390 @default.
- W4313376818 cites W1515260750 @default.
- W4313376818 cites W1526448477 @default.
- W4313376818 cites W1527404918 @default.
- W4313376818 cites W1568750314 @default.
- W4313376818 cites W1579103205 @default.
- W4313376818 cites W1800770505 @default.
- W4313376818 cites W1919115790 @default.
- W4313376818 cites W1928303171 @default.
- W4313376818 cites W1974684256 @default.
- W4313376818 cites W1981166064 @default.
- W4313376818 cites W1988031989 @default.
- W4313376818 cites W1995744312 @default.
- W4313376818 cites W1996202980 @default.
- W4313376818 cites W1996749929 @default.
- W4313376818 cites W2001758550 @default.
- W4313376818 cites W2004503041 @default.
- W4313376818 cites W2011451968 @default.
- W4313376818 cites W2012987505 @default.
- W4313376818 cites W2029007974 @default.
- W4313376818 cites W2043856037 @default.
- W4313376818 cites W2049170267 @default.
- W4313376818 cites W2054855625 @default.
- W4313376818 cites W2060320549 @default.
- W4313376818 cites W2064879068 @default.
- W4313376818 cites W2079813256 @default.
- W4313376818 cites W2084761937 @default.
- W4313376818 cites W2085396070 @default.
- W4313376818 cites W2091953393 @default.
- W4313376818 cites W2098677328 @default.
- W4313376818 cites W2105808377 @default.
- W4313376818 cites W2111537010 @default.
- W4313376818 cites W2118556518 @default.
- W4313376818 cites W2122506044 @default.
- W4313376818 cites W2126283955 @default.
- W4313376818 cites W2126568240 @default.
- W4313376818 cites W2145012483 @default.
- W4313376818 cites W2148894882 @default.
- W4313376818 cites W2152892875 @default.
- W4313376818 cites W2154393492 @default.
- W4313376818 cites W2154684602 @default.
- W4313376818 cites W2161671739 @default.
- W4313376818 cites W2163520160 @default.
- W4313376818 cites W4313331533 @default.
- W4313376818 cites W4313341425 @default.
- W4313376818 doi "https://doi.org/10.4049/jimmunol.162.8.4731" @default.
- W4313376818 hasPublicationYear "1999" @default.
- W4313376818 type Work @default.
- W4313376818 citedByCount "57" @default.
- W4313376818 countsByYear W43133768182012 @default.
- W4313376818 countsByYear W43133768182020 @default.
- W4313376818 countsByYear W43133768182022 @default.
- W4313376818 countsByYear W43133768182023 @default.
- W4313376818 crossrefType "journal-article" @default.
- W4313376818 hasAuthorship W4313376818A5032172517 @default.
- W4313376818 hasAuthorship W4313376818A5032782967 @default.
- W4313376818 hasAuthorship W4313376818A5073371361 @default.
- W4313376818 hasBestOaLocation W43133768181 @default.
- W4313376818 hasConcept C101762097 @default.
- W4313376818 hasConcept C104317684 @default.
- W4313376818 hasConcept C1292079 @default.
- W4313376818 hasConcept C132376346 @default.
- W4313376818 hasConcept C138885662 @default.
- W4313376818 hasConcept C150194340 @default.
- W4313376818 hasConcept C153911025 @default.
- W4313376818 hasConcept C179926584 @default.
- W4313376818 hasConcept C207936829 @default.
- W4313376818 hasConcept C27153228 @default.
- W4313376818 hasConcept C2775890610 @default.
- W4313376818 hasConcept C2778814158 @default.
- W4313376818 hasConcept C41895202 @default.
- W4313376818 hasConcept C54355233 @default.
- W4313376818 hasConcept C86339819 @default.
- W4313376818 hasConcept C86803240 @default.
- W4313376818 hasConcept C95444343 @default.
- W4313376818 hasConceptScore W4313376818C101762097 @default.
- W4313376818 hasConceptScore W4313376818C104317684 @default.
- W4313376818 hasConceptScore W4313376818C1292079 @default.
- W4313376818 hasConceptScore W4313376818C132376346 @default.
- W4313376818 hasConceptScore W4313376818C138885662 @default.
- W4313376818 hasConceptScore W4313376818C150194340 @default.
- W4313376818 hasConceptScore W4313376818C153911025 @default.
- W4313376818 hasConceptScore W4313376818C179926584 @default.
- W4313376818 hasConceptScore W4313376818C207936829 @default.
- W4313376818 hasConceptScore W4313376818C27153228 @default.
- W4313376818 hasConceptScore W4313376818C2775890610 @default.
- W4313376818 hasConceptScore W4313376818C2778814158 @default.
- W4313376818 hasConceptScore W4313376818C41895202 @default.