Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313376891> ?p ?o ?g. }
Showing items 1 to 55 of
55
with 100 items per page.
- W4313376891 endingPage "553" @default.
- W4313376891 startingPage "546" @default.
- W4313376891 abstract "Summary The degree and persistence of immunologic unresponsiveness, induced in the adult guinea pig with a single intravenous injection of protein antigen in saline, depended on the time relationships between administration of the suppressing and sensitizing injections. Unresponsiveness was maximal when suppressing and sensitizing injections were administered concurrently. As the interval between the suppressing and sensitizing injections was increased, progressively less unresponsiveness resulted. Animals receiving a “suppressing” intravenous antigen injection 6–12 weeks prior to sensitization developed increased 7 Sγ1 antibody titers, suggesting that the suppressing injection was itself potentially immunogenic. It was also possible to induce immunologic unresponsiveness as late as 10 days after administration of a sensitizing injection of antigen, at a time when the animal already manifested a weak immune response; however, larger doses of suppressing antigen were required. Delayed skin reactivity was most readily suppressed by intravenous antigen and last to recover. Hemolytic antibody production followed an intermediate course, while 7 Sγ1 antibody production was most resistant to suppression and the first to recover. The differences in suppressibility of these immune functions may reflect differences in the sensitivity of the techniques used to measure them or may indicate that these immune functions arise independently, possibly from different cell lines." @default.
- W4313376891 created "2023-01-06" @default.
- W4313376891 creator A5058290100 @default.
- W4313376891 creator A5086838899 @default.
- W4313376891 date "1966-03-01" @default.
- W4313376891 modified "2023-09-26" @default.
- W4313376891 title "Immunologic Unresponsiveness in the Adult Guinea Pig" @default.
- W4313376891 doi "https://doi.org/10.4049/jimmunol.96.3.546" @default.
- W4313376891 hasPublicationYear "1966" @default.
- W4313376891 type Work @default.
- W4313376891 citedByCount "4" @default.
- W4313376891 crossrefType "journal-article" @default.
- W4313376891 hasAuthorship W4313376891A5058290100 @default.
- W4313376891 hasAuthorship W4313376891A5086838899 @default.
- W4313376891 hasBestOaLocation W43133768911 @default.
- W4313376891 hasConcept C126322002 @default.
- W4313376891 hasConcept C147483822 @default.
- W4313376891 hasConcept C159654299 @default.
- W4313376891 hasConcept C203014093 @default.
- W4313376891 hasConcept C22889606 @default.
- W4313376891 hasConcept C2776217527 @default.
- W4313376891 hasConcept C2778815084 @default.
- W4313376891 hasConcept C32611913 @default.
- W4313376891 hasConcept C71924100 @default.
- W4313376891 hasConcept C8891405 @default.
- W4313376891 hasConceptScore W4313376891C126322002 @default.
- W4313376891 hasConceptScore W4313376891C147483822 @default.
- W4313376891 hasConceptScore W4313376891C159654299 @default.
- W4313376891 hasConceptScore W4313376891C203014093 @default.
- W4313376891 hasConceptScore W4313376891C22889606 @default.
- W4313376891 hasConceptScore W4313376891C2776217527 @default.
- W4313376891 hasConceptScore W4313376891C2778815084 @default.
- W4313376891 hasConceptScore W4313376891C32611913 @default.
- W4313376891 hasConceptScore W4313376891C71924100 @default.
- W4313376891 hasConceptScore W4313376891C8891405 @default.
- W4313376891 hasIssue "3" @default.
- W4313376891 hasLocation W43133768911 @default.
- W4313376891 hasOpenAccess W4313376891 @default.
- W4313376891 hasPrimaryLocation W43133768911 @default.
- W4313376891 hasRelatedWork W1484759019 @default.
- W4313376891 hasRelatedWork W1539989077 @default.
- W4313376891 hasRelatedWork W1602183989 @default.
- W4313376891 hasRelatedWork W1845358311 @default.
- W4313376891 hasRelatedWork W2040191638 @default.
- W4313376891 hasRelatedWork W2148908215 @default.
- W4313376891 hasRelatedWork W2220102944 @default.
- W4313376891 hasRelatedWork W2221445727 @default.
- W4313376891 hasRelatedWork W2381991529 @default.
- W4313376891 hasRelatedWork W2384171498 @default.
- W4313376891 hasVolume "96" @default.
- W4313376891 isParatext "false" @default.
- W4313376891 isRetracted "false" @default.
- W4313376891 workType "article" @default.