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- W4313376905 abstract "Abstract Whether γδ T lymphocytes respond to microbial Ags or to inducible host Ags remains a matter of controversy. Using several different disease models and mouse strains, we and others have seen that Vγ6/Vδ1 γδ T cells preferentially increase among the γδ T cells infiltrating inflamed tissues. However, it was not clear whether bacteria are necessary to bring about this response. Therefore, we have reexamined this question using a disease model in which inflammation is induced by a purely autoimmune process involving no bacteria, bacterial products, or other foreign material: testicular cell-induced autoimmune orchitis. Using this model we found that γδ T cells were still plentiful among the infiltrating T lymphocytes, being 9- to 10-fold more prevalent than in spleen, and that Vγ6/Vδ1+ cells again represented the predominant γδ T cell type. This finding shows that the response of the Vγ6/Vδ1+ subset does not, in fact, depend upon the presence of bacteria or bacterial products. The stimulus triggering the response of the Vγ6/Vδ1 γδ T cells appears to be neither foreign nor organ-specific in origin, but instead consists of a self-derived host Ag or signal induced during the inflammatory process." @default.
- W4313376905 created "2023-01-06" @default.
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- W4313376905 date "1999-04-15" @default.
- W4313376905 modified "2023-10-05" @default.
- W4313376905 title "Inflammation Alone Evokes the Response of a TCR-Invariant Mouse γδ T Cell Subset" @default.
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- W4313376905 doi "https://doi.org/10.4049/jimmunol.162.8.4910" @default.
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