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• W4313376913 endingPage "587" @default.
• W4313376913 startingPage "580" @default.
• W4313376913 abstract "Abstract In the following study, we demonstrate that medium responder PVG rats immunized i.p. with OVA complexed to the adjuvant aluminum hydroxide exhibit a moderate IgE response (400–1000 ng/ml). In these rats, we demonstrate that underlying the MHC class II-restricted CD4+ T cell response, there is an MHC class I-restricted CD8+ T cell component that plays an important role in restricting the magnitude and duration of the IgE response. We show that in vivo depletion of CD8+ T cells effects a massive increase in IgE (20-fold), and that they are MHC class I-restricted, OVA-specific, cytolytic cells that universally produce IFN-γ (25–69 ng/ml) and IL-2 (7.6–22 U/ml), and occasionally secrete IL-4 (68–81 U/ml IL-4), and when adoptively transferred into CD8-depleted recipients, can effect a significant reduction in IgE (3- to 50-fold). We also demonstrate that this in vivo inhibition of IgE is dependent on the Ag-specific activation of the CD8+ T cells, and that the activated CD8+ T cells will suppress total/bystander IgE in an Ag-nonspecific manner. These data are consistent with a growing literature demonstrating sensitization of MHC class I-restricted CD8+ T cells by exogenous protein Ags delivered to mucosal sites, and may represent a mechanism whereby a selective pressure can be applied on the functional outcome of an immunoglobulin response to environmental allergens." @default.
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• W4313376913 date "1998-01-15" @default.
• W4313376913 modified "2023-09-27" @default.
• W4313376913 title "Ovalbumin-Specific, MHC Class I-Restricted, αβ-Positive, Tc1 and Tc0 CD8+ T Cell Clones Mediate the In Vivo Inhibition of Rat IgE" @default.
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• W4313376913 doi "https://doi.org/10.4049/jimmunol.160.2.580" @default.
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