FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313376916> ?p ?o ?g. }

• W4313376916 endingPage "4389" @default.
• W4313376916 startingPage "4385" @default.
• W4313376916 abstract "Abstract A mutation in the human (hu) IL-4Rα, Q576R, has been linked with allergy in humans. Increased sensitivity of patients cells with this mutation to IL-4 suggest that a Q576R change enhances IL-4 signaling. To directly test this hypothesis, we analyzed the ability of huIL-4Rα cDNA bearing the Q576R and Y575F mutations to signal tyrosine phosphorylation, DNA-binding activity, proliferation, protection from apoptosis, and CD23 induction in response to huIL-4 in murine cells. Responses generated by the Q576R and Y575F mutants were similar to those of the wild-type receptor, using various concentrations of huIL-4 and times of stimulation. These results indicate that neither the Q576R nor the Y575F mutations have a significant direct effect on IL-4 signal transduction, and that hypersensitive induction of CD23 in cells derived from human allergy patients may be due to different and/or additional alterations in the IL-4 signaling pathway." @default.
• W4313376916 created "2023-01-06" @default.
• W4313376916 creator A5000996407 @default.
• W4313376916 creator A5024554835 @default.
• W4313376916 creator A5048079346 @default.
• W4313376916 creator A5073089482 @default.
• W4313376916 creator A5078024279 @default.
• W4313376916 creator A5082176880 @default.
• W4313376916 date "1999-04-15" @default.
• W4313376916 modified "2023-10-17" @default.
• W4313376916 title "Cutting Edge: Effects of an Allergy-Associated Mutation in the Human IL-4Rα (Q576R) on Human IL-4-Induced Signal Transduction" @default.
• W4313376916 cites W1545898053 @default.
• W4313376916 cites W1572009433 @default.
• W4313376916 cites W1976805459 @default.
• W4313376916 cites W1985113364 @default.
• W4313376916 cites W1987758746 @default.
• W4313376916 cites W1997785224 @default.
• W4313376916 cites W2002169500 @default.
• W4313376916 cites W2009867390 @default.
• W4313376916 cites W2028699958 @default.
• W4313376916 cites W2037061225 @default.
• W4313376916 cites W2047153130 @default.
• W4313376916 cites W2066808953 @default.
• W4313376916 cites W2073476576 @default.
• W4313376916 cites W2080575389 @default.
• W4313376916 cites W2094472942 @default.
• W4313376916 cites W2096661621 @default.
• W4313376916 cites W2117387349 @default.
• W4313376916 cites W2124222608 @default.
• W4313376916 cites W2144120552 @default.
• W4313376916 cites W2144281476 @default.
• W4313376916 cites W2154684298 @default.
• W4313376916 cites W2161450196 @default.
• W4313376916 cites W2164774128 @default.
• W4313376916 cites W27114251 @default.
• W4313376916 cites W4241462674 @default.
• W4313376916 cites W4313333735 @default.
• W4313376916 cites W4313347695 @default.
• W4313376916 doi "https://doi.org/10.4049/jimmunol.162.8.4385" @default.
• W4313376916 hasPublicationYear "1999" @default.
• W4313376916 type Work @default.
• W4313376916 citedByCount "26" @default.
• W4313376916 countsByYear W43133769162013 @default.
• W4313376916 countsByYear W43133769162014 @default.
• W4313376916 crossrefType "journal-article" @default.
• W4313376916 hasAuthorship W4313376916A5000996407 @default.
• W4313376916 hasAuthorship W4313376916A5024554835 @default.
• W4313376916 hasAuthorship W4313376916A5048079346 @default.
• W4313376916 hasAuthorship W4313376916A5073089482 @default.
• W4313376916 hasAuthorship W4313376916A5078024279 @default.
• W4313376916 hasAuthorship W4313376916A5082176880 @default.
• W4313376916 hasBestOaLocation W43133769161 @default.
• W4313376916 hasConcept C104317684 @default.
• W4313376916 hasConcept C11960822 @default.
• W4313376916 hasConcept C141105273 @default.
• W4313376916 hasConcept C143065580 @default.
• W4313376916 hasConcept C15152581 @default.
• W4313376916 hasConcept C153911025 @default.
• W4313376916 hasConcept C159654299 @default.
• W4313376916 hasConcept C170493617 @default.
• W4313376916 hasConcept C187882448 @default.
• W4313376916 hasConcept C203014093 @default.
• W4313376916 hasConcept C207480886 @default.
• W4313376916 hasConcept C2777553839 @default.
• W4313376916 hasConcept C34814297 @default.
• W4313376916 hasConcept C501734568 @default.
• W4313376916 hasConcept C502942594 @default.
• W4313376916 hasConcept C54355233 @default.
• W4313376916 hasConcept C55493867 @default.
• W4313376916 hasConcept C62478195 @default.
• W4313376916 hasConcept C86803240 @default.
• W4313376916 hasConcept C95444343 @default.
• W4313376916 hasConceptScore W4313376916C104317684 @default.
• W4313376916 hasConceptScore W4313376916C11960822 @default.
• W4313376916 hasConceptScore W4313376916C141105273 @default.
• W4313376916 hasConceptScore W4313376916C143065580 @default.
• W4313376916 hasConceptScore W4313376916C15152581 @default.
• W4313376916 hasConceptScore W4313376916C153911025 @default.
• W4313376916 hasConceptScore W4313376916C159654299 @default.
• W4313376916 hasConceptScore W4313376916C170493617 @default.
• W4313376916 hasConceptScore W4313376916C187882448 @default.
• W4313376916 hasConceptScore W4313376916C203014093 @default.
• W4313376916 hasConceptScore W4313376916C207480886 @default.
• W4313376916 hasConceptScore W4313376916C2777553839 @default.
• W4313376916 hasConceptScore W4313376916C34814297 @default.
• W4313376916 hasConceptScore W4313376916C501734568 @default.
• W4313376916 hasConceptScore W4313376916C502942594 @default.
• W4313376916 hasConceptScore W4313376916C54355233 @default.
• W4313376916 hasConceptScore W4313376916C55493867 @default.
• W4313376916 hasConceptScore W4313376916C62478195 @default.
• W4313376916 hasConceptScore W4313376916C86803240 @default.
• W4313376916 hasConceptScore W4313376916C95444343 @default.
• W4313376916 hasIssue "8" @default.
• W4313376916 hasLocation W43133769161 @default.
• W4313376916 hasOpenAccess W4313376916 @default.
• W4313376916 hasPrimaryLocation W43133769161 @default.
• W4313376916 hasRelatedWork W1531825933 @default.
• W4313376916 hasRelatedWork W1965702849 @default.

• next