Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313376923> ?p ?o ?g. }
Showing items 1 to 54 of
54
with 100 items per page.
- W4313376923 endingPage "790" @default.
- W4313376923 startingPage "781" @default.
- W4313376923 abstract "Summary Serum levels of 7 S γ2-, 7 S γ1-, γ1A- and γ1M- globulins and of hemagglutinating antibody were determined in 10 strains of mice immunized with hemocyanin and ferritin. The effect of five factors on the response to immunization were investigated: a) difference between single and repeated injections of antigen, b) differences between antigen administration in saline and in adjuvant, c) effect of different time intervals between first and second administration of antigen, d) effect of adjuvant alone and e) mouse strain differences. A single injection of antigens in saline produced no appreciable change in the serum immunoglobulin levels. After a single injection of antigen emulsified in Freund's adjuvant, the levels of the 7 S γ1-globulins showed a two- to five-fold increase. After a second injection of the antigens in adjuvant, 7 S γ1-globulins showed a 10- to 30-fold increase. The absolute and relative changes in the other three immunoglobulins (7 S γ2, γ1A(IgA) and γ1M(IgM)-globulins) following primary and secondary challenge were not as marked as the increase in 7 S γ1-globulins. Repeated injections of antigen in saline produced a greater increase of γ1M(IgM)-globulins than did several injections of antigen in Freund's adjuvant. The response of specific immunoglobulins to antigenic challenge is strain dependent. The most notable strains were a) the C57BL mice, which showed marked increase of γ1M(IgM) and γ1A (IgA)-globulins and b) the white Swiss (GP) mice, which showed very little increase in γ1M-(IgM)- and γ1A(IgA)-globulins while developing the highest levels of 7 S γ1-globulin. Injection of adjuvant without antigen had no notable effect except in C57 strains of mice, where marked increases of γ1M(IgM)-globulins occurred." @default.
- W4313376923 created "2023-01-06" @default.
- W4313376923 creator A5012527995 @default.
- W4313376923 creator A5053124148 @default.
- W4313376923 creator A5087599224 @default.
- W4313376923 date "1965-11-01" @default.
- W4313376923 modified "2023-10-17" @default.
- W4313376923 title "The Immunoglobulins of Mice" @default.
- W4313376923 doi "https://doi.org/10.4049/jimmunol.95.5.781" @default.
- W4313376923 hasPublicationYear "1965" @default.
- W4313376923 type Work @default.
- W4313376923 citedByCount "18" @default.
- W4313376923 countsByYear W43133769232023 @default.
- W4313376923 crossrefType "journal-article" @default.
- W4313376923 hasAuthorship W4313376923A5012527995 @default.
- W4313376923 hasAuthorship W4313376923A5053124148 @default.
- W4313376923 hasAuthorship W4313376923A5087599224 @default.
- W4313376923 hasBestOaLocation W43133769231 @default.
- W4313376923 hasConcept C147483822 @default.
- W4313376923 hasConcept C159654299 @default.
- W4313376923 hasConcept C185592680 @default.
- W4313376923 hasConcept C203014093 @default.
- W4313376923 hasConcept C2777863537 @default.
- W4313376923 hasConcept C79162176 @default.
- W4313376923 hasConcept C81358767 @default.
- W4313376923 hasConcept C86803240 @default.
- W4313376923 hasConceptScore W4313376923C147483822 @default.
- W4313376923 hasConceptScore W4313376923C159654299 @default.
- W4313376923 hasConceptScore W4313376923C185592680 @default.
- W4313376923 hasConceptScore W4313376923C203014093 @default.
- W4313376923 hasConceptScore W4313376923C2777863537 @default.
- W4313376923 hasConceptScore W4313376923C79162176 @default.
- W4313376923 hasConceptScore W4313376923C81358767 @default.
- W4313376923 hasConceptScore W4313376923C86803240 @default.
- W4313376923 hasIssue "5" @default.
- W4313376923 hasLocation W43133769231 @default.
- W4313376923 hasOpenAccess W4313376923 @default.
- W4313376923 hasPrimaryLocation W43133769231 @default.
- W4313376923 hasRelatedWork W102807906 @default.
- W4313376923 hasRelatedWork W1604222187 @default.
- W4313376923 hasRelatedWork W1908196998 @default.
- W4313376923 hasRelatedWork W1945848208 @default.
- W4313376923 hasRelatedWork W2040575687 @default.
- W4313376923 hasRelatedWork W2088137261 @default.
- W4313376923 hasRelatedWork W2313203183 @default.
- W4313376923 hasRelatedWork W4313372951 @default.
- W4313376923 hasRelatedWork W4313375523 @default.
- W4313376923 hasRelatedWork W4313376923 @default.
- W4313376923 hasVolume "95" @default.
- W4313376923 isParatext "false" @default.
- W4313376923 isRetracted "false" @default.
- W4313376923 workType "article" @default.