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• W4313376978 endingPage "5168" @default.
• W4313376978 startingPage "5163" @default.
• W4313376978 abstract "Abstract Recent investigation has indicated that TGF-β1, the macrophage (Mφ) deactivator, may attenuate Mφ-mediated acute glomerular injury. Using stromelysin as an indicator, this study investigated whether and how endogenous TGF-β1 modulates the glomerular cell activation triggered by Mφ. Rat mesangial cells were stably transfected with a cDNA encoding the active form of TGF-β1 and a cDNA coding for a dominant-negative mutant of the TGF-βR type II. Compared with mock-transfected cells, TGF-β1 transfectants exhibited blunted expression of stromelysin in response to the Mφ-derived, inflammatory cytokine IL-1β. In contrast, mesangial cells expressing the dominant-interfering TGF-βR showed enhanced expression of stromelysin in response to IL-1β, suggesting that endogenous TGF-β functions as an autocrine inhibitor of the IL-1 response. In isolated, normal rat glomeruli, externally added TGF-β1 suppressed the induction of stromelysin by mediators that were elaborated by activated Mφ. Similarly, when isolated, nephritic glomeruli producing the active form of TGF-β1 were stimulated by IL-1β or Mφ-conditioned medium, the induction of stromelysin was dramatically suppressed as compared with normal glomeruli. To investigate whether endogenous TGF-β1 affects the glomerular cell activation triggered by Mφ, a technique for adoptive Mφ transfer was used. LPS-stimulated reporter Mφ were transferred into either normal rat glomeruli or nephritic glomeruli expressing active TGF-β1. In the normal glomeruli, stromelysin expression was markedly induced in resident cells after the transfer of activated Mφ. This induction was substantially repressed in those glomeruli producing active TGF-β1. These results reinforce the idea that TGF-β1 is an endogenous defender that attenuates certain actions of infiltrating Mφ in the glomerulus." @default.
• W4313376978 created "2023-01-06" @default.
• W4313376978 creator A5058680290 @default.
• W4313376978 date "1998-05-15" @default.
• W4313376978 modified "2023-09-26" @default.
• W4313376978 title "TGF-β1 as an Endogenous Defender Against Macrophage-Triggered Stromelysin Gene Expression in the Glomerulus" @default.
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• W4313376978 doi "https://doi.org/10.4049/jimmunol.160.10.5163" @default.
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