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- W4313376982 abstract "Abstract IL-1α and IL-1β are proinflammatory cytokines involved in the pathogenesis of many infectious and noninfectious inflammatory diseases. To reduce IL-1 toxicity, extracellular domains of the soluble (s) IL-1R are shed from cell membranes and prevent triggering of cell-bound receptors. We investigated to what extent murine sIL-1RI can neutralize the IL-1 produced by LPS-stimulated macrophages. When mouse peritoneal macrophages were incubated with LPS, addition of sIL-1RI significantly inhibited the bioactivity of IL-1. Stimulation of cells with sIL-1RI alone induced no bioactive IL-1. When immunoreactive cytokine concentrations were measured with specific radioimmunoassays, sIL-1RI alone appeared to induce a significant release of IL-1α in a concentration-dependent manner. This effect was independent of new protein synthesis. The production of IL-1β or TNF-α was not influenced by sIL-1RI. There was no interference of sIL-1RI with the IL-1α radioimmunoassay. In mice, an i.v. injection of sIL-RI alone induced a rapid release of IL-1α, but not of TNF-α or IL-1β. Treatment of mice with sIL-1RI improved the survival during a lethal infection with Candida albicans. In conclusion, sIL-1RI induces a rapid release of IL-1α from cells, as well as into the systemic circulation. Although this IL-1α may be inactivated in circulation by the same sIL-1RI, this phenomenon probably has immunostimulatory effects at local levels where the sIL-1RI-induced IL-1α acts in a paracrine or autocrine manner." @default.
- W4313376982 created "2023-01-06" @default.
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- W4313376982 date "1999-04-15" @default.
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- W4313376982 title "Soluble Murine IL-1 Receptor Type I Induces Release of Constitutive IL-1α" @default.
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- W4313376982 doi "https://doi.org/10.4049/jimmunol.162.8.4876" @default.
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