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- W4313377133 abstract "Abstract CD8+ T cells are effective mediators of immunity against Listeria monocytogenes, but the mechanisms by which they provide antilisterial immunity are poorly understood. CD8+ T cells efficiently lyse target cells in vitro by at least two independent pathways. To test the hypothesis that CD8+ T cell-mediated immunity to L. monocytogenes is dependent on perforin or CD95 (Fas, Apo-1), we used C57Bl/6 (B6) and perforin-deficient (PO) mice to generate CD8+ T cell lines specific for the L. monocytogenes-encoded Ag listeriolysin O (LLO). Both lines specifically produce IFN-γ and TNF-α, and mediate target cell lysis in vitro. Cytolysis mediated by the PO-derived CD8+ T cell line is delayed relative to the B6-derived line and is completely inhibited by anti-CD95 Abs. In vivo, PO-derived CD8+ T cells provide specific antilisterial immunity in B6 hosts, CD95-deficient hosts, and IFN-γ-depleted hosts. However, PO-derived CD8+ T cells fail to provide antilisterial immunity in hosts depleted of TNF-α. These results indicate that single Ag-specific CD8+ T cells derived from PO mice can mediate antilisterial immunity by a mechanism that is independent of CD95 or IFN-γ, but requires TNF-α." @default.
- W4313377133 created "2023-01-06" @default.
- W4313377133 creator A5016130507 @default.
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- W4313377133 date "1998-01-15" @default.
- W4313377133 modified "2023-10-17" @default.
- W4313377133 title "Perforin-Deficient CD8+ T Cells Provide Immunity to <i>Listeria monocytogenes</i> by a Mechanism That Is Independent of CD95 and IFN-γ but Requires TNF-α" @default.
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- W4313377133 doi "https://doi.org/10.4049/jimmunol.160.2.898" @default.
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