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• W4313377149 abstract "Abstract Members of the NF-κB/Rel family of transcription factors are involved in many aspects of B lymphocyte development and function. NF-κB is constitutively active in these cells, in contrast with most other cell types. In the inactive form, NF-κB/Rel proteins are sequestered in the cytoplasm by members of the IκB family of NF-κB inhibitors. When activated, NF-κB is translocated to the nucleus, a process that involves the phosphorylation and proteasomal degradation of IκB proteins. Thus, NF-κB activation is accompanied by the rapid turnover of IκB proteins. We show that while this “classical” mode of NF-κB activation is a uniform feature of IgM+ B cell lines, all IgG+ B cells analyzed contain nuclear NF-κB yet have stable IκBα, IκBβ, and IκBε. Furthermore, Iκβε levels are at least 10 times lower in IgG+ B cells than in IgM+ B cells, an additional indication that the regulation of constitutive NF-κB activity in these two types of B cells is fundamentally different. These data imply the existence of a novel mechanism of NF-κB activation in IgG+ B cells that operates independently of IκB degradation. They further suggest that different isoforms of the B cell receptor may have distinct roles in regulating NF-κB activity." @default.
• W4313377149 created "2023-01-06" @default.
• W4313377149 creator A5030201904 @default.
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• W4313377149 date "1999-07-01" @default.
• W4313377149 modified "2023-10-17" @default.
• W4313377149 title "Constitutive Nuclear Translocation of NF-κB in B Cells in the Absence of IκB Degradation" @default.
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• W4313377149 doi "https://doi.org/10.4049/jimmunol.163.1.269" @default.
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