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- W4313377174 abstract "Abstract Many CTL epitopes of clinical importance, particularly those derived from tumor Ags, display relatively poor MHC binding affinity and stability. Because in vivo immunogenicity, and thus the efficacy of peptide-based vaccines, is thought to be determined by MHC/peptide complex stability, there is a need to develop a simple strategy for enhancing the binding of suboptimal epitopes. Toward this goal, the ability to enhance suboptimal peptides through covalent linkage to β2-microglobulin (β2m) was explored. Two suboptimal variants of a high-affinity Db-restricted influenza nucleoprotein peptide were covalently linked, via a polypeptide spacer, to the amino terminus of human β2m and the recombinant fusion proteins expressed in Escherichia coli. When compared with their uncoupled counterparts, the β2m-linked epitopes display enhanced MHC stabilization and antigenicity. Thus, tethering epitopes to β2m provides a simple method for augmenting the biological activity of suboptimal peptides and could be useful in the design of peptide-based vaccines or immunotherapeutics." @default.
- W4313377174 created "2023-01-06" @default.
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- W4313377174 date "1999-05-15" @default.
- W4313377174 modified "2023-10-18" @default.
- W4313377174 title "Covalent Linkage to β2-Microglobulin Enhances the MHC Stability and Antigenicity of Suboptimal CTL Epitopes" @default.
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- W4313377174 doi "https://doi.org/10.4049/jimmunol.162.10.6024" @default.
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