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- W4313379029 abstract "Abstract An effective host response to a microbial pathogen requires both the generation of effector T cells as well as formation of durable T cell memory. Dendritic cells (DCs) play a central role in initiating the adaptive T cell response to microbial infection, and multiple distinct DC subsets have the potential to take up and present microbial antigen. However, the contribution of different DC subsets to the generation of effector and memory CD8+ T cells in vivo following infection and the DC dependent mechanisms to account for this dichotomy remain incompletely understood. Here we show that the two major migratory respiratory DC (RDC) subsets responding in the lung draining lymph nodes to influenza virus infection, CD103+ and CD11bhi RDC, activate naïve virus-specific CD8+ T cells along distinctly different differentiation pathways. CD103+ RDC in vivo stimulate the generation of activated CD8+ T cells with features characteristic of CD8+ T effectors that is activated T cells which efficiently leave the lymph nodes and home to the infected respiratory tract. In contrast, stimulation of naïve virus-specific CD8+ T cells by CD11bhi RDC give rise to CD8+ T effectors which are preferentially retained within the draining lymph nodes during the acute phase of infection, and which exhibits properties of central memory CD8+ cells. DC-dependent cellular and molecular basis for refining this dichotomy for in vivo CD8+ T cell differentiation are further delineated." @default.
- W4313379029 created "2023-01-06" @default.
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- W4313379029 date "2013-05-01" @default.
- W4313379029 modified "2023-09-27" @default.
- W4313379029 title "Distinct dendritic cell subsets dictate the fate decision between effector and memory CD8+ T cell differentiation (P6172)" @default.
- W4313379029 doi "https://doi.org/10.4049/jimmunol.190.supp.189.1" @default.
- W4313379029 hasPublicationYear "2013" @default.
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