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- W4313379416 abstract "Abstract Self-antigen recognition has been shown to be instrumental for the maintenance of the pool of circulating naïve T cells. While the mechanisms of immune diversity maintenance in the naive T cell repertoire have been explored, how immune diversity is maintained in the face of antigen selection is less understood. Data from several studies show that self-peptide presented by FRCs in the secondary lymphoid organs help maintain the diversity of the naïve T cell repertoire. We propose that an analogous mechanism is in play even during the effector stage of an immune response, which if left unchecked would bias the repertoire towards clones with higher affinity for the foreign antigen. In this study, we report a clone-specific regulation of the diversity in the face of antigen selection. Our data show that CD8+ T cell clones selected on the same self peptide compete for this self-antigen presented by stromal cells even during the clonal expansion phase in an effector response. The supply of self-peptide and hence IL-7 becomes limiting as the clone increases in size and the ability for the clone to further expand is curtailed. Such a mechanism would explain the maintenance of the diversity of the immune repertoire even through an antigen-driven response as T cells transition from being naïve to effectors." @default.
- W4313379416 created "2023-01-06" @default.
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- W4313379416 date "2015-05-01" @default.
- W4313379416 modified "2023-09-30" @default.
- W4313379416 title "Maintenance of immune diversity during an effector T cell response in face of antigen selection (IRC8P.444)" @default.
- W4313379416 doi "https://doi.org/10.4049/jimmunol.194.supp.129.8" @default.
- W4313379416 hasPublicationYear "2015" @default.
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