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- W4313379418 abstract "Abstract The roles of Notch1 and Notch2 in T cell function have been well studied, but the functional roles of Notch in B cells have not been extensively investigated, except for Notch2 involvement in peripheral marginal zone B cell differentiation. This study examined the roles of Notch1 in murine primary B cells. We found that the intracellular domain of Notch1 could substitute for Notch2 in marginal zone B cell differentiation, and that Notch1 expression was important for further activation of B cells. During B cell activation by B cell receptor ligation, Notch1 was up-regulated while Notch2 was not. In addition, Notch1 up-regulation itself did not contribute to the further activation of B cells, but the Notch ligand was important for Notch1-mediated further B cell activation. Moreover, Notch1 increased antibody secretion from activated B cells. These data suggest that Notch1 is more important for B cell activation than Notch2, while Notch2 is more important for marginal zone B cell differentiation." @default.
- W4313379418 created "2023-01-06" @default.
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- W4313379418 date "2015-05-01" @default.
- W4313379418 modified "2023-10-16" @default.
- W4313379418 title "Notch1 is an important secondary stimulator for activated B cells (IRM10P.606)" @default.
- W4313379418 doi "https://doi.org/10.4049/jimmunol.194.supp.131.4" @default.
- W4313379418 hasPublicationYear "2015" @default.
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