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- W4313379468 abstract "Abstract CD1-dependent NK1+ T cells rapidly produce IL-4 upon stimulation through the TCR. These cells may therefore play an important role in the initiation of Th2 responses. Here, we show that NK1+ T cells constitutively express receptors for IL-12 and IFN-γ, and that IL-12 induces production of perforin in these cells. Moreover, while IL-12 induces high levels of IFN-γ and cytotoxic activity of hepatic or splenic mononuclear cells against tumor cells, this effect of IL-12 is significantly reduced in CD1-deficient mice with impaired NK1+ T cells development. These results indicate that NK1+ T cells play a critical role in IL-12-induced production of IFN-γ to initiate Th1 immune responses and as IL-12-induced cytotoxic effector cells to initiate antitumor immunity." @default.
- W4313379468 created "2023-01-06" @default.
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- W4313379468 date "1998-01-01" @default.
- W4313379468 modified "2023-10-17" @default.
- W4313379468 title "Cutting Edge: Critical Role of NK1+ T Cells in IL-12-Induced Immune Responses In Vivo" @default.
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- W4313379468 doi "https://doi.org/10.4049/jimmunol.160.1.16" @default.
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