FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313379596> ?p ?o ?g. }

• W4313379596 endingPage "60" @default.
• W4313379596 startingPage "55" @default.
• W4313379596 abstract "The cell motility of smooth muscle cells (SMCs) is essential for vascular and internal organ development and tissue regeneration in response to damage. Cell migration requires dynamic changes in the actin-cytoskeleton via the p-21 activated kinase (Pak)-Cofilin signaling cascade, which is the central axis of the actin filaments. We previously identified that the Inka2 gene was preferentially expressed in the central nervous system (CNS) and revealed that Inka2 directly binds Pak4 to suppress its kinase activity, thereby regulating actin de-polymerization in dendritic spine formation of the forebrain neurons. However, its physiological significance outside the CNS remains unclear. Here we determined the Inka2 expression profile in various organs using in situ hybridization analysis and lacZ staining on Inka2flox/+ mice. Robust Inka2 expression was consistently detected in the SMCs of many peripheral organs, including the arteries, esophagus, stomach, intestine, and bladder. The scratch assay was used on primary cultured SMCs and revealed that Inka2-/- SMC exhibits accelerated cell migration ability without a change in the cell proliferation rate. Inka2-/- SMCs displayed Cofilin activation/phosphorylation, a downstream molecule of Pak4 signal cascade. These results suggest that Inka2 regulates SMC motility through modulating actin reorganization as the endogenous inhibitor of Pak4." @default.
• W4313379596 created "2023-01-06" @default.
• W4313379596 creator A5025454325 @default.
• W4313379596 creator A5055138525 @default.
• W4313379596 creator A5087128721 @default.
• W4313379596 date "2023-02-01" @default.
• W4313379596 modified "2023-10-17" @default.
• W4313379596 title "Inka2 expression in smooth muscle cells and its involvement in cell migration" @default.
• W4313379596 cites W1179860925 @default.
• W4313379596 cites W1974959940 @default.
• W4313379596 cites W2028363992 @default.
• W4313379596 cites W2058986600 @default.
• W4313379596 cites W2082024168 @default.
• W4313379596 cites W2097161820 @default.
• W4313379596 cites W2099473671 @default.
• W4313379596 cites W2101798777 @default.
• W4313379596 cites W2118544280 @default.
• W4313379596 cites W2139397108 @default.
• W4313379596 cites W2139782237 @default.
• W4313379596 cites W2140831214 @default.
• W4313379596 cites W2142046844 @default.
• W4313379596 cites W2142563473 @default.
• W4313379596 cites W2151344601 @default.
• W4313379596 cites W2163732061 @default.
• W4313379596 cites W2165101502 @default.
• W4313379596 cites W2165962006 @default.
• W4313379596 cites W2178394372 @default.
• W4313379596 cites W2316822356 @default.
• W4313379596 cites W2409577105 @default.
• W4313379596 cites W2686055919 @default.
• W4313379596 cites W2745366275 @default.
• W4313379596 cites W2884353594 @default.
• W4313379596 cites W2921452976 @default.
• W4313379596 cites W3001455676 @default.
• W4313379596 cites W3098621528 @default.
• W4313379596 cites W3126290622 @default.
• W4313379596 cites W4225627202 @default.
• W4313379596 cites W4307639683 @default.
• W4313379596 cites W4308365361 @default.
• W4313379596 doi "https://doi.org/10.1016/j.bbrc.2022.12.068" @default.
• W4313379596 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36586159" @default.
• W4313379596 hasPublicationYear "2023" @default.
• W4313379596 type Work @default.
• W4313379596 citedByCount "0" @default.
• W4313379596 crossrefType "journal-article" @default.
• W4313379596 hasAuthorship W4313379596A5025454325 @default.
• W4313379596 hasAuthorship W4313379596A5055138525 @default.
• W4313379596 hasAuthorship W4313379596A5087128721 @default.
• W4313379596 hasConcept C125705527 @default.
• W4313379596 hasConcept C137738243 @default.
• W4313379596 hasConcept C141073059 @default.
• W4313379596 hasConcept C142669718 @default.
• W4313379596 hasConcept C1491633281 @default.
• W4313379596 hasConcept C151166631 @default.
• W4313379596 hasConcept C169760540 @default.
• W4313379596 hasConcept C2776601116 @default.
• W4313379596 hasConcept C2779715522 @default.
• W4313379596 hasConcept C2781099445 @default.
• W4313379596 hasConcept C2993400109 @default.
• W4313379596 hasConcept C529278444 @default.
• W4313379596 hasConcept C55493867 @default.
• W4313379596 hasConcept C58207958 @default.
• W4313379596 hasConcept C62478195 @default.
• W4313379596 hasConcept C86803240 @default.
• W4313379596 hasConcept C95444343 @default.
• W4313379596 hasConceptScore W4313379596C125705527 @default.
• W4313379596 hasConceptScore W4313379596C137738243 @default.
• W4313379596 hasConceptScore W4313379596C141073059 @default.
• W4313379596 hasConceptScore W4313379596C142669718 @default.
• W4313379596 hasConceptScore W4313379596C1491633281 @default.
• W4313379596 hasConceptScore W4313379596C151166631 @default.
• W4313379596 hasConceptScore W4313379596C169760540 @default.
• W4313379596 hasConceptScore W4313379596C2776601116 @default.
• W4313379596 hasConceptScore W4313379596C2779715522 @default.
• W4313379596 hasConceptScore W4313379596C2781099445 @default.
• W4313379596 hasConceptScore W4313379596C2993400109 @default.
• W4313379596 hasConceptScore W4313379596C529278444 @default.
• W4313379596 hasConceptScore W4313379596C55493867 @default.
• W4313379596 hasConceptScore W4313379596C58207958 @default.
• W4313379596 hasConceptScore W4313379596C62478195 @default.
• W4313379596 hasConceptScore W4313379596C86803240 @default.
• W4313379596 hasConceptScore W4313379596C95444343 @default.
• W4313379596 hasFunder F4320322638 @default.
• W4313379596 hasFunder F4320334764 @default.
• W4313379596 hasLocation W43133795961 @default.
• W4313379596 hasLocation W43133795962 @default.
• W4313379596 hasOpenAccess W4313379596 @default.
• W4313379596 hasPrimaryLocation W43133795961 @default.
• W4313379596 hasRelatedWork W1999152177 @default.
• W4313379596 hasRelatedWork W2013940103 @default.
• W4313379596 hasRelatedWork W2084295528 @default.
• W4313379596 hasRelatedWork W2104001125 @default.
• W4313379596 hasRelatedWork W2104155917 @default.
• W4313379596 hasRelatedWork W2131554707 @default.
• W4313379596 hasRelatedWork W2131939253 @default.
• W4313379596 hasRelatedWork W3144553512 @default.
• W4313379596 hasRelatedWork W3162819630 @default.
• W4313379596 hasRelatedWork W4313379596 @default.

• next