FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313379614> ?p ?o ?g. }

• W4313379614 endingPage "463755" @default.
• W4313379614 startingPage "463755" @default.
• W4313379614 abstract "We developed a computational framework that integrates commercial software components to perform customizable technoeconomic feasibility analyses. The use of multiple software packages overcomes the shortcomings of each to provide a detailed simulation that can be used for sensitivity analyses and optimizations. In this paper, the framework was used to evaluate the performance of monoclonal antibody capture processes. To this end, the simulation framework incorporated dynamic models for the affinity chromatography step that were validated with experimental breakthrough curves. The results were integrated with an Intelligen SuperPro Designer process simulation for the evaluation of key performance indicators of the operations. As proof of concept, the framework was used to perform a sensitivity analysis and optimization for a case study in which we sought to compare membrane and resin chromatography for disposable and reusable batch capture platforms. Two membranes and one resin were selected for the capture media, which yielded six process alternatives to compare. The objective functions were set to be cost of goods, process time, and buffer utilization. The results of the optimization of these process alternatives were a set of operating conditions that display tradeoffs between competing objectives. From this application exercise, we conclude that the framework can handle multiple variables and objectives, and it is adaptable to platforms with different chromatography media and operating modes. Additionally, the framework is capable of providing ad hoc analyses for decision making in a specific production context." @default.
• W4313379614 created "2023-01-06" @default.
• W4313379614 creator A5028571067 @default.
• W4313379614 creator A5040559768 @default.
• W4313379614 creator A5059137545 @default.
• W4313379614 creator A5065893686 @default.
• W4313379614 date "2023-01-01" @default.
• W4313379614 modified "2023-10-10" @default.
• W4313379614 title "Computational framework for the techno-economic analysis of monoclonal antibody capture chromatography platforms" @default.
• W4313379614 cites W1965424864 @default.
• W4313379614 cites W1976826478 @default.
• W4313379614 cites W1977254640 @default.
• W4313379614 cites W2008408455 @default.
• W4313379614 cites W2013552755 @default.
• W4313379614 cites W2024648685 @default.
• W4313379614 cites W2024991751 @default.
• W4313379614 cites W2043677245 @default.
• W4313379614 cites W2047188276 @default.
• W4313379614 cites W2061765969 @default.
• W4313379614 cites W2081209603 @default.
• W4313379614 cites W2082187902 @default.
• W4313379614 cites W2087887771 @default.
• W4313379614 cites W2090712456 @default.
• W4313379614 cites W2301882830 @default.
• W4313379614 cites W2307576161 @default.
• W4313379614 cites W2611980186 @default.
• W4313379614 cites W2754167587 @default.
• W4313379614 cites W2791683138 @default.
• W4313379614 cites W2888987699 @default.
• W4313379614 cites W2895898542 @default.
• W4313379614 cites W2913004967 @default.
• W4313379614 cites W2945634632 @default.
• W4313379614 cites W2971657288 @default.
• W4313379614 cites W2981386474 @default.
• W4313379614 cites W3004331198 @default.
• W4313379614 cites W3026830821 @default.
• W4313379614 cites W3033490909 @default.
• W4313379614 cites W3038170273 @default.
• W4313379614 cites W3046115843 @default.
• W4313379614 cites W3089495595 @default.
• W4313379614 cites W3155123963 @default.
• W4313379614 doi "https://doi.org/10.1016/j.chroma.2022.463755" @default.
• W4313379614 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36586284" @default.
• W4313379614 hasPublicationYear "2023" @default.
• W4313379614 type Work @default.
• W4313379614 citedByCount "2" @default.
• W4313379614 countsByYear W43133796142023 @default.
• W4313379614 crossrefType "journal-article" @default.
• W4313379614 hasAuthorship W4313379614A5028571067 @default.
• W4313379614 hasAuthorship W4313379614A5040559768 @default.
• W4313379614 hasAuthorship W4313379614A5059137545 @default.
• W4313379614 hasAuthorship W4313379614A5065893686 @default.
• W4313379614 hasConcept C111919701 @default.
• W4313379614 hasConcept C127413603 @default.
• W4313379614 hasConcept C151730666 @default.
• W4313379614 hasConcept C177264268 @default.
• W4313379614 hasConcept C199360897 @default.
• W4313379614 hasConcept C21200559 @default.
• W4313379614 hasConcept C21880701 @default.
• W4313379614 hasConcept C24326235 @default.
• W4313379614 hasConcept C2777904410 @default.
• W4313379614 hasConcept C2779343474 @default.
• W4313379614 hasConcept C41008148 @default.
• W4313379614 hasConcept C86803240 @default.
• W4313379614 hasConcept C98045186 @default.
• W4313379614 hasConceptScore W4313379614C111919701 @default.
• W4313379614 hasConceptScore W4313379614C127413603 @default.
• W4313379614 hasConceptScore W4313379614C151730666 @default.
• W4313379614 hasConceptScore W4313379614C177264268 @default.
• W4313379614 hasConceptScore W4313379614C199360897 @default.
• W4313379614 hasConceptScore W4313379614C21200559 @default.
• W4313379614 hasConceptScore W4313379614C21880701 @default.
• W4313379614 hasConceptScore W4313379614C24326235 @default.
• W4313379614 hasConceptScore W4313379614C2777904410 @default.
• W4313379614 hasConceptScore W4313379614C2779343474 @default.
• W4313379614 hasConceptScore W4313379614C41008148 @default.
• W4313379614 hasConceptScore W4313379614C86803240 @default.
• W4313379614 hasConceptScore W4313379614C98045186 @default.
• W4313379614 hasFunder F4320306076 @default.
• W4313379614 hasFunder F4320322927 @default.
• W4313379614 hasFunder F4320332161 @default.
• W4313379614 hasFunder F4320337354 @default.
• W4313379614 hasLocation W43133796141 @default.
• W4313379614 hasLocation W43133796142 @default.
• W4313379614 hasOpenAccess W4313379614 @default.
• W4313379614 hasPrimaryLocation W43133796141 @default.
• W4313379614 hasRelatedWork W1987706094 @default.
• W4313379614 hasRelatedWork W1997355275 @default.
• W4313379614 hasRelatedWork W2008764675 @default.
• W4313379614 hasRelatedWork W2015462925 @default.
• W4313379614 hasRelatedWork W2122745100 @default.
• W4313379614 hasRelatedWork W2204346447 @default.
• W4313379614 hasRelatedWork W2355215981 @default.
• W4313379614 hasRelatedWork W2366115308 @default.
• W4313379614 hasRelatedWork W3015644425 @default.
• W4313379614 hasRelatedWork W2012842278 @default.
• W4313379614 hasVolume "1689" @default.
• W4313379614 isParatext "false" @default.

• next