Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313379625> ?p ?o ?g. }
- W4313379625 endingPage "122561" @default.
- W4313379625 startingPage "122561" @default.
- W4313379625 abstract "The clinical utility of 7-ethyl-10-hydroxycamptothecin (SN-38) is hampered by its low water solubility and reduced bioactivity at neutral or alkaline conditions. The rational design of an effective drug delivery system that can significantly enhance the therapeutic index of SN-38 and achieve complete tumor regression still remains a challenge. Herein, chitosan-based hybrid nanoparticles system co-loading with chemotherapeutic drug SN-38 and gold nanorods (AuNRs) was engineered for effective combinational photothermal-chemotherapy. To increase the solubility of SN-38, soluble polymeric prodrug poly (l-glutamic acid)-SN38 (l-PGA-SN38) was firstly synthesized and then complexed with chitosan to form stable nanomedicine via a mild and facile way without using any organic solvent or surfactant. Upon introducing AuNRs into chitosan-based nanomedicine by coordination interaction between the amine group of chitosan and AuNRs, the hybrid nanoparticles exhibited distinct synergistic therapeutic effect compared with single chemotherapy or photothermal treatment in vitro and in vivo. Almost complete tumor regression was achieved after 21-day treatment of the developed hybrid nanoparticles and showed no recurrence for at least 60 days." @default.
- W4313379625 created "2023-01-06" @default.
- W4313379625 creator A5006288241 @default.
- W4313379625 creator A5033452791 @default.
- W4313379625 creator A5047690033 @default.
- W4313379625 creator A5051779422 @default.
- W4313379625 creator A5057287134 @default.
- W4313379625 creator A5064842058 @default.
- W4313379625 creator A5089447277 @default.
- W4313379625 date "2023-02-01" @default.
- W4313379625 modified "2023-09-23" @default.
- W4313379625 title "Gold nanorods-loaded chitosan-based nanomedicine platform enabling an effective tumor regression in vivo" @default.
- W4313379625 cites W1879356743 @default.
- W4313379625 cites W1991130662 @default.
- W4313379625 cites W1995742898 @default.
- W4313379625 cites W2006304277 @default.
- W4313379625 cites W2025295644 @default.
- W4313379625 cites W2053622985 @default.
- W4313379625 cites W2064788032 @default.
- W4313379625 cites W2075062190 @default.
- W4313379625 cites W2096439168 @default.
- W4313379625 cites W2160045751 @default.
- W4313379625 cites W2324564321 @default.
- W4313379625 cites W2343301825 @default.
- W4313379625 cites W2538231602 @default.
- W4313379625 cites W2602511245 @default.
- W4313379625 cites W2607156656 @default.
- W4313379625 cites W2725218484 @default.
- W4313379625 cites W2755415289 @default.
- W4313379625 cites W2776575854 @default.
- W4313379625 cites W2776768256 @default.
- W4313379625 cites W2800041021 @default.
- W4313379625 cites W2806983345 @default.
- W4313379625 cites W2809366270 @default.
- W4313379625 cites W2889646458 @default.
- W4313379625 cites W2901115555 @default.
- W4313379625 cites W2904625209 @default.
- W4313379625 cites W2905549162 @default.
- W4313379625 cites W2917945750 @default.
- W4313379625 cites W3093043826 @default.
- W4313379625 cites W3096928710 @default.
- W4313379625 cites W3123431144 @default.
- W4313379625 cites W3136760058 @default.
- W4313379625 cites W3198176864 @default.
- W4313379625 cites W4211168195 @default.
- W4313379625 cites W4289833735 @default.
- W4313379625 doi "https://doi.org/10.1016/j.ijpharm.2022.122561" @default.
- W4313379625 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36586640" @default.
- W4313379625 hasPublicationYear "2023" @default.
- W4313379625 type Work @default.
- W4313379625 citedByCount "0" @default.
- W4313379625 crossrefType "journal-article" @default.
- W4313379625 hasAuthorship W4313379625A5006288241 @default.
- W4313379625 hasAuthorship W4313379625A5033452791 @default.
- W4313379625 hasAuthorship W4313379625A5047690033 @default.
- W4313379625 hasAuthorship W4313379625A5051779422 @default.
- W4313379625 hasAuthorship W4313379625A5057287134 @default.
- W4313379625 hasAuthorship W4313379625A5064842058 @default.
- W4313379625 hasAuthorship W4313379625A5089447277 @default.
- W4313379625 hasConcept C126201875 @default.
- W4313379625 hasConcept C15083742 @default.
- W4313379625 hasConcept C150903083 @default.
- W4313379625 hasConcept C155574463 @default.
- W4313379625 hasConcept C155672457 @default.
- W4313379625 hasConcept C171250308 @default.
- W4313379625 hasConcept C178790620 @default.
- W4313379625 hasConcept C182606246 @default.
- W4313379625 hasConcept C185592680 @default.
- W4313379625 hasConcept C192562407 @default.
- W4313379625 hasConcept C207001950 @default.
- W4313379625 hasConcept C21951064 @default.
- W4313379625 hasConcept C2779732960 @default.
- W4313379625 hasConcept C2779820397 @default.
- W4313379625 hasConcept C86803240 @default.
- W4313379625 hasConceptScore W4313379625C126201875 @default.
- W4313379625 hasConceptScore W4313379625C15083742 @default.
- W4313379625 hasConceptScore W4313379625C150903083 @default.
- W4313379625 hasConceptScore W4313379625C155574463 @default.
- W4313379625 hasConceptScore W4313379625C155672457 @default.
- W4313379625 hasConceptScore W4313379625C171250308 @default.
- W4313379625 hasConceptScore W4313379625C178790620 @default.
- W4313379625 hasConceptScore W4313379625C182606246 @default.
- W4313379625 hasConceptScore W4313379625C185592680 @default.
- W4313379625 hasConceptScore W4313379625C192562407 @default.
- W4313379625 hasConceptScore W4313379625C207001950 @default.
- W4313379625 hasConceptScore W4313379625C21951064 @default.
- W4313379625 hasConceptScore W4313379625C2779732960 @default.
- W4313379625 hasConceptScore W4313379625C2779820397 @default.
- W4313379625 hasConceptScore W4313379625C86803240 @default.
- W4313379625 hasFunder F4320321001 @default.
- W4313379625 hasFunder F4320338464 @default.
- W4313379625 hasLocation W43133796251 @default.
- W4313379625 hasLocation W43133796252 @default.
- W4313379625 hasOpenAccess W4313379625 @default.
- W4313379625 hasPrimaryLocation W43133796251 @default.
- W4313379625 hasRelatedWork W2725461327 @default.
- W4313379625 hasRelatedWork W2802579958 @default.
- W4313379625 hasRelatedWork W2898875021 @default.