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• W4313379629 endingPage "102846" @default.
• W4313379629 startingPage "102846" @default.
• W4313379629 abstract "Escherichia coli K-12 possesses two versions of Trk/Ktr/HKT-type potassium ion (K+) transporters, TrkG and TrkH. The current paradigm is that TrkG and TrkH have largely identical characteristics, and little information is available regarding their functional differences. Here, we show using cation uptake experiments with K+ transporter knockout mutants that TrkG and TrkH have distinct ion transport activities and physiological roles. K+-transport by TrkG required Na+, whereas TrkH-mediated K+ uptake was not affected by Na+. An aspartic acid located five residues away from a critical glycine in the third pore-forming region might be involved in regulation of Na+-dependent activation of TrkG. In addition, we found that TrkG but not TrkH had Na+ uptake activity. Our analysis of K+ transport mutants revealed that TrkH supported cell growth more than TrkG; however, TrkG was able to complement loss of TrkH-mediated K+ uptake in E. coli. Furthermore, we determined that transcription of trkG in E. coli was downregulated but not completely silenced by the xenogeneic silencing factor H-NS (histone-like nucleoid structuring protein or heat-stable nucleoid-structuring protein). Taken together, the transport function of TrkG is clearly distinct from that of TrkH, and TrkG seems to have been accepted by E. coli during evolution as a K+ uptake system that coexists with TrkH." @default.
• W4313379629 created "2023-01-06" @default.
• W4313379629 creator A5010271995 @default.
• W4313379629 creator A5019027605 @default.
• W4313379629 creator A5025091647 @default.
• W4313379629 creator A5033174688 @default.
• W4313379629 creator A5040275479 @default.
• W4313379629 creator A5043714375 @default.
• W4313379629 creator A5045367486 @default.
• W4313379629 creator A5088237819 @default.
• W4313379629 date "2023-02-01" @default.
• W4313379629 modified "2023-10-14" @default.
• W4313379629 title "Two Trk/Ktr/HKT-type potassium transporters, TrkG and TrkH, perform distinct functions in Escherichia coli K-12" @default.
• W4313379629 cites W1505385667 @default.
• W4313379629 cites W1513679181 @default.
• W4313379629 cites W1514145656 @default.
• W4313379629 cites W1541707791 @default.
• W4313379629 cites W1548713443 @default.
• W4313379629 cites W1576095742 @default.
• W4313379629 cites W1586165461 @default.
• W4313379629 cites W1595101124 @default.
• W4313379629 cites W1763857691 @default.
• W4313379629 cites W1782067245 @default.
• W4313379629 cites W1918513717 @default.
• W4313379629 cites W1933665514 @default.
• W4313379629 cites W1972413387 @default.
• W4313379629 cites W1973352749 @default.
• W4313379629 cites W1974469549 @default.
• W4313379629 cites W1976126780 @default.
• W4313379629 cites W1987469737 @default.
• W4313379629 cites W1996002552 @default.
• W4313379629 cites W1998585137 @default.
• W4313379629 cites W1999011602 @default.
• W4313379629 cites W2000017565 @default.
• W4313379629 cites W2000994784 @default.
• W4313379629 cites W2006670481 @default.
• W4313379629 cites W2012160968 @default.
• W4313379629 cites W2014361215 @default.
• W4313379629 cites W2025205859 @default.
• W4313379629 cites W2028841756 @default.
• W4313379629 cites W2033313498 @default.
• W4313379629 cites W2034169170 @default.
• W4313379629 cites W2035915986 @default.
• W4313379629 cites W2036952012 @default.
• W4313379629 cites W2037944731 @default.
• W4313379629 cites W2043128798 @default.
• W4313379629 cites W2046200067 @default.
• W4313379629 cites W2049051285 @default.
• W4313379629 cites W2050839170 @default.
• W4313379629 cites W2059955112 @default.
• W4313379629 cites W2060930951 @default.
• W4313379629 cites W2069698199 @default.
• W4313379629 cites W2078420488 @default.
• W4313379629 cites W2082602413 @default.
• W4313379629 cites W2088986479 @default.
• W4313379629 cites W2089352446 @default.
• W4313379629 cites W2089954238 @default.
• W4313379629 cites W2090352676 @default.
• W4313379629 cites W2092542394 @default.
• W4313379629 cites W2096309846 @default.
• W4313379629 cites W2099224768 @default.
• W4313379629 cites W2111967267 @default.
• W4313379629 cites W2115928499 @default.
• W4313379629 cites W2116137883 @default.
• W4313379629 cites W2119106014 @default.
• W4313379629 cites W2120556435 @default.
• W4313379629 cites W2120645278 @default.
• W4313379629 cites W2123589399 @default.
• W4313379629 cites W2130298560 @default.
• W4313379629 cites W2135737750 @default.
• W4313379629 cites W2137421512 @default.
• W4313379629 cites W2138391026 @default.
• W4313379629 cites W2138952930 @default.
• W4313379629 cites W2140250382 @default.
• W4313379629 cites W2146627752 @default.
• W4313379629 cites W2146978320 @default.
• W4313379629 cites W2152619379 @default.
• W4313379629 cites W2155037228 @default.
• W4313379629 cites W2158259282 @default.
• W4313379629 cites W2159975205 @default.
• W4313379629 cites W2160174395 @default.
• W4313379629 cites W2161075828 @default.
• W4313379629 cites W2169719841 @default.
• W4313379629 cites W2277394881 @default.
• W4313379629 cites W2578653290 @default.
• W4313379629 cites W2612515716 @default.
• W4313379629 cites W2648083391 @default.
• W4313379629 cites W2800222644 @default.
• W4313379629 cites W2955698285 @default.
• W4313379629 cites W2982693331 @default.
• W4313379629 cites W2998993230 @default.
• W4313379629 cites W2999853337 @default.
• W4313379629 cites W3003423249 @default.
• W4313379629 cites W3004297519 @default.
• W4313379629 cites W3211795435 @default.
• W4313379629 cites W4223552703 @default.
• W4313379629 cites W55296984 @default.
• W4313379629 doi "https://doi.org/10.1016/j.jbc.2022.102846" @default.

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