Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313379700> ?p ?o ?g. }
- W4313379700 endingPage "614" @default.
- W4313379700 startingPage "600" @default.
- W4313379700 abstract "The emergence of drug resistance in cancer cells is among the major challenges for treating cancer. In the last few years, the co-delivery of drug and siRNA has shown promising results against drug-resistant cancers. In the present study, we developed mesoporous silica-based multifunctional nanocarrier for co-delivery against drug-resistant triple-negative breast cancer (TNBC) cells. We synthesized the nanocarrier by modifying mesoporous silica nanoparticles with poly-L-arginine, polyethylene glycol and AS1411 aptamer to impart siRNA binding ability, biocompatibility, and cancer cell specificity, respectively. We optimized the loading of doxorubicin (DOX) within the developed nanocarrier to avoid interference with siRNA binding. We ascertained the target specificity by performing a receptor blockade assay during cellular uptake studies. The cytotoxic efficacy of DOX and siRNA co-delivered using the developed nanocarrier was assessed using DOX-resistant MDA-MB-231 TNBC cells. The nanocarrier exhibited >10-fold and 40-fold reduction in the IC50 values of DOX due to co-delivery with BCl-xL and BCL-2 siRNA, respectively. The results were further validated using a 3-D in vitro cell culture system. This study demonstrates that the targeted co-delivery of drug and siRNA has a strong potential to overcome drug resistance in TNBC cells." @default.
- W4313379700 created "2023-01-06" @default.
- W4313379700 creator A5043487791 @default.
- W4313379700 creator A5062766784 @default.
- W4313379700 creator A5065558226 @default.
- W4313379700 creator A5087968395 @default.
- W4313379700 date "2023-02-01" @default.
- W4313379700 modified "2023-10-18" @default.
- W4313379700 title "Nucleolin aptamer conjugated MSNPs-PLR-PEG multifunctional nanoconstructs for targeted co-delivery of anticancer drug and siRNA to counter drug resistance in TNBC" @default.
- W4313379700 cites W1587071366 @default.
- W4313379700 cites W1968293067 @default.
- W4313379700 cites W1968351069 @default.
- W4313379700 cites W1968602934 @default.
- W4313379700 cites W1969346276 @default.
- W4313379700 cites W1975145454 @default.
- W4313379700 cites W1979665070 @default.
- W4313379700 cites W1982106711 @default.
- W4313379700 cites W1983361018 @default.
- W4313379700 cites W1985713382 @default.
- W4313379700 cites W1991953785 @default.
- W4313379700 cites W1995224853 @default.
- W4313379700 cites W2004635629 @default.
- W4313379700 cites W2008139865 @default.
- W4313379700 cites W2008171455 @default.
- W4313379700 cites W2010251891 @default.
- W4313379700 cites W2014928486 @default.
- W4313379700 cites W2018494545 @default.
- W4313379700 cites W2021385919 @default.
- W4313379700 cites W2029431569 @default.
- W4313379700 cites W2034791599 @default.
- W4313379700 cites W2037235549 @default.
- W4313379700 cites W2040662045 @default.
- W4313379700 cites W2043156676 @default.
- W4313379700 cites W2044626782 @default.
- W4313379700 cites W2047311008 @default.
- W4313379700 cites W2050273631 @default.
- W4313379700 cites W2056402768 @default.
- W4313379700 cites W2065122365 @default.
- W4313379700 cites W2065355693 @default.
- W4313379700 cites W2072860434 @default.
- W4313379700 cites W2078532650 @default.
- W4313379700 cites W2085439839 @default.
- W4313379700 cites W2093585643 @default.
- W4313379700 cites W2114505219 @default.
- W4313379700 cites W2115755457 @default.
- W4313379700 cites W2123183032 @default.
- W4313379700 cites W2124367950 @default.
- W4313379700 cites W2125287840 @default.
- W4313379700 cites W2134539328 @default.
- W4313379700 cites W2135842528 @default.
- W4313379700 cites W2173249787 @default.
- W4313379700 cites W2174168899 @default.
- W4313379700 cites W2230985085 @default.
- W4313379700 cites W2338436183 @default.
- W4313379700 cites W2468127999 @default.
- W4313379700 cites W2591798217 @default.
- W4313379700 cites W2743818239 @default.
- W4313379700 cites W2759576182 @default.
- W4313379700 cites W2802887023 @default.
- W4313379700 cites W2804830927 @default.
- W4313379700 cites W2807770298 @default.
- W4313379700 cites W2910346583 @default.
- W4313379700 cites W2910798735 @default.
- W4313379700 cites W2916073481 @default.
- W4313379700 cites W2916911849 @default.
- W4313379700 cites W2930441154 @default.
- W4313379700 cites W2947447234 @default.
- W4313379700 cites W2979402130 @default.
- W4313379700 cites W2979636644 @default.
- W4313379700 cites W2980258067 @default.
- W4313379700 cites W3007426356 @default.
- W4313379700 cites W3016733806 @default.
- W4313379700 cites W4220867677 @default.
- W4313379700 doi "https://doi.org/10.1016/j.ijbiomac.2022.12.266" @default.
- W4313379700 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36586658" @default.
- W4313379700 hasPublicationYear "2023" @default.
- W4313379700 type Work @default.
- W4313379700 citedByCount "5" @default.
- W4313379700 countsByYear W43133797002023 @default.
- W4313379700 crossrefType "journal-article" @default.
- W4313379700 hasAuthorship W4313379700A5043487791 @default.
- W4313379700 hasAuthorship W4313379700A5062766784 @default.
- W4313379700 hasAuthorship W4313379700A5065558226 @default.
- W4313379700 hasAuthorship W4313379700A5087968395 @default.
- W4313379700 hasConcept C114851261 @default.
- W4313379700 hasConcept C121608353 @default.
- W4313379700 hasConcept C126322002 @default.
- W4313379700 hasConcept C126511603 @default.
- W4313379700 hasConcept C128972844 @default.
- W4313379700 hasConcept C141071460 @default.
- W4313379700 hasConcept C153911025 @default.
- W4313379700 hasConcept C161790260 @default.
- W4313379700 hasConcept C178790620 @default.
- W4313379700 hasConcept C18150654 @default.
- W4313379700 hasConcept C185592680 @default.
- W4313379700 hasConcept C2776694085 @default.
- W4313379700 hasConcept C2777496208 @default.
- W4313379700 hasConcept C2779820397 @default.