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- W4313379723 endingPage "102670" @default.
- W4313379723 startingPage "102670" @default.
- W4313379723 abstract "Stroke is a devastating cause of global morbidity and mortality. Ischemic brain injury triggers a profound local and systemic immune response that participates in stroke pathophysiology. In turn, this immune response has emerged as a potential therapeutic target. In order to maximize its therapeutic potential, it is critical to understand how the immune response to ischemic brain injury is affected by age - the strongest non-modifiable risk factor for stroke. The development of multi-omics and single-cell technologies has provided a more comprehensive characterization of transcriptional and cellular changes that occur during aging. In this review, we summarize recent advances in our understanding of how age-related immune alterations shape differential stroke outcomes in older versus younger organisms, highlighting studies in both experimental mouse models and patient cohorts. Wherever possible, we emphasize outstanding questions that present important avenues for future investigation with therapeutic value for the aging population." @default.
- W4313379723 created "2023-01-06" @default.
- W4313379723 creator A5023049098 @default.
- W4313379723 creator A5055364501 @default.
- W4313379723 creator A5086830763 @default.
- W4313379723 creator A5088034421 @default.
- W4313379723 date "2023-02-01" @default.
- W4313379723 modified "2023-10-02" @default.
- W4313379723 title "The age-dependent immune response to ischemic stroke" @default.
- W4313379723 cites W1550954183 @default.
- W4313379723 cites W1972214068 @default.
- W4313379723 cites W1978927200 @default.
- W4313379723 cites W1982730030 @default.
- W4313379723 cites W2024661673 @default.
- W4313379723 cites W2026089271 @default.
- W4313379723 cites W2044159907 @default.
- W4313379723 cites W2058478749 @default.
- W4313379723 cites W2061769617 @default.
- W4313379723 cites W2067028731 @default.
- W4313379723 cites W2083900005 @default.
- W4313379723 cites W2113333920 @default.
- W4313379723 cites W2116228592 @default.
- W4313379723 cites W2128591402 @default.
- W4313379723 cites W2129438107 @default.
- W4313379723 cites W2130386049 @default.
- W4313379723 cites W2156751422 @default.
- W4313379723 cites W2159103481 @default.
- W4313379723 cites W2161099598 @default.
- W4313379723 cites W2161962636 @default.
- W4313379723 cites W2163410184 @default.
- W4313379723 cites W2293892300 @default.
- W4313379723 cites W2337334490 @default.
- W4313379723 cites W2562743466 @default.
- W4313379723 cites W2585661817 @default.
- W4313379723 cites W2609163538 @default.
- W4313379723 cites W2738997953 @default.
- W4313379723 cites W2757279402 @default.
- W4313379723 cites W2759715932 @default.
- W4313379723 cites W2790139801 @default.
- W4313379723 cites W2793562257 @default.
- W4313379723 cites W2802167882 @default.
- W4313379723 cites W2802894273 @default.
- W4313379723 cites W2884081989 @default.
- W4313379723 cites W2896734003 @default.
- W4313379723 cites W2899249431 @default.
- W4313379723 cites W2904203401 @default.
- W4313379723 cites W2906438829 @default.
- W4313379723 cites W2906480617 @default.
- W4313379723 cites W2921406167 @default.
- W4313379723 cites W2945711076 @default.
- W4313379723 cites W2975507539 @default.
- W4313379723 cites W2989979068 @default.
- W4313379723 cites W2990744279 @default.
- W4313379723 cites W3000061011 @default.
- W4313379723 cites W3010530525 @default.
- W4313379723 cites W3010926230 @default.
- W4313379723 cites W3014940784 @default.
- W4313379723 cites W3022448963 @default.
- W4313379723 cites W3026206677 @default.
- W4313379723 cites W3034822765 @default.
- W4313379723 cites W3042406747 @default.
- W4313379723 cites W3046885739 @default.
- W4313379723 cites W3080907278 @default.
- W4313379723 cites W3091416909 @default.
- W4313379723 cites W3098744674 @default.
- W4313379723 cites W3122324184 @default.
- W4313379723 cites W3125742210 @default.
- W4313379723 cites W3128620467 @default.
- W4313379723 cites W3134758701 @default.
- W4313379723 cites W3135791721 @default.
- W4313379723 cites W3156018770 @default.
- W4313379723 cites W3159561089 @default.
- W4313379723 cites W3163657510 @default.
- W4313379723 cites W3165520347 @default.
- W4313379723 cites W3179857518 @default.
- W4313379723 cites W3182212846 @default.
- W4313379723 cites W3182997864 @default.
- W4313379723 cites W3193314050 @default.
- W4313379723 cites W3194095572 @default.
- W4313379723 cites W3197233575 @default.
- W4313379723 cites W3199261356 @default.
- W4313379723 cites W3215112832 @default.
- W4313379723 cites W4213236742 @default.
- W4313379723 cites W4214570803 @default.
- W4313379723 cites W4220661922 @default.
- W4313379723 cites W4220760869 @default.
- W4313379723 cites W4220790583 @default.
- W4313379723 cites W4223635857 @default.
- W4313379723 cites W4223931196 @default.
- W4313379723 cites W4226047661 @default.
- W4313379723 cites W4226156505 @default.
- W4313379723 cites W4226217894 @default.
- W4313379723 cites W4244124467 @default.
- W4313379723 cites W4280532787 @default.
- W4313379723 cites W4283016888 @default.
- W4313379723 cites W4283382760 @default.
- W4313379723 cites W4283724042 @default.
- W4313379723 doi "https://doi.org/10.1016/j.conb.2022.102670" @default.