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- W4313379824 abstract "Atrial fibrillation (AF), the clinically most common form of arrhythmia, is usually classified based on its duration: ranging from paroxysmal AF, consisting of self-terminating episodes lasting typically less than 7 days, to persistent and long-lasting persistent or chronic AF, in which AF fails to self-terminate. 1 Lévy S. Camm A.J. Saksena S. et al. Working Group on Arrhythmias, Working Group on Cardiac Pacing of the European Society of Cardiology, North American Society of Pacing and Electrophysiology. International consensus on nomenclature and classification of atrial fibrillation: a collaborative project of the Working Group on Arrhythmias and the Working Group on Cardiac Pacing of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology. Europace. 2003; 5: 119-122 Crossref PubMed Scopus (88) Google Scholar In all the different forms, electrical remodelling occurs. This remodelling further increases ectopic-triggered activity and provides an electrical substrate even more prone to re-entry formation—the 2 main arrhythmogenic mechanisms in AF—thereby facilitating the occurrence and maintenance of AF, as described in the term “AF begets AF” by the Allessie group in 1995. 2 Wijffels M.C. Kirchhof C.J. Dorland R. Allessie M.A. Atrial fibrillation begets atrial fibrillation: a study in awake chronically instrumented goats. Circulation. 1995; 92: 1954-1968 Crossref PubMed Scopus (2945) Google Scholar Differential Sodium Current Remodelling Identifies Distinct Cellular Proarrhythmic Mechanisms in Paroxysmal vs Persistent Atrial FibrillationCanadian Journal of CardiologyVol. 39Issue 3PreviewThe cellular mechanisms underlying progression from paroxysmal to persistent atrial fibrillation (AF) are not fully understood, but alterations in (late) sodium current (INa) have been proposed. Human studies investigating electrophysiological changes at the paroxysmal stage of AF are sparse, with the majority employing right atrial appendage cardiomyocytes (CMs). We here investigated action potential (AP) characteristics and (late) INa remodelling in left atrial appendage CMs (LAA-CMs) from patients with paroxysmal and persistent AF and patients in sinus rhythm (SR), as well as the potential contribution of the “neuronal” sodium channel SCN10A/NaV1.8. Full-Text PDF Open Access" @default.
- W4313379824 created "2023-01-06" @default.
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- W4313379824 date "2023-03-01" @default.
- W4313379824 modified "2023-10-14" @default.
- W4313379824 title "Differential Remodeling of Late INa in Paroxysmal and Persistent AF: Another Piece in the Complex Picture of Electrical Remodelling in AF" @default.
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- W4313379824 doi "https://doi.org/10.1016/j.cjca.2022.12.022" @default.
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