FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313379829> ?p ?o ?g. }

• W4313379829 endingPage "1111" @default.
• W4313379829 startingPage "1093" @default.
• W4313379829 abstract "Preclinical studies have proven that nanosecond pulsed electric field (nsPEF) ablation can be a safe and effective treatment for humans with unresectable liver cancer that are ineligible for thermal ablation. The concomitant activation of antitumor immunity by nsPEF can also potentially prevent tumor recurrence. However, whether nsPEF exhibits similar efficacy in a clinical setting remains to be investigated. A prospective clinical trial (clinicaltrials.gov identifier: NCT04039747) was conducted to evaluate the safety and efficacy of ultrasound (US)-guided nsPEF ablation in 15 patients with unresectable liver cancer that were ineligible for thermal ablation. We found that nsPEF ablation was safe and produced a 12-month recurrence-free survival (RFS) and local RFS of 60% (9/15) and 86.7% (13/15), respectively, in the enrolled patients. Integrative proteomic and metabolomic analysis showed that sphingolipid metabolism was the most significantly enriched pathway in patient sera after nsPEF without recurrence within 8 months. A similar upregulation of sphingolipid metabolism was observed in the intratumoral mononuclear phagocytes (MNPs), rather than other immune and nonimmune cells, of an nsPEF-treated mouse model. We then demonstrated that lymphocyte antigen 6 complex, locus C2-positive (Ly6c2+ ) monocytes first differentiated into Ly6c2+ monocyte-derived macrophages with an increase in sphingolipid metabolic activity, and subsequently into Ly6c2+ dendritic cells (DCs). Ly6c2+ DCs communicated with CD8+ T cells and increased the proportions of IFN-γ+ CD8+ memory T cells after nsPEF, and this finding was subsequently confirmed by depletion of liver Ly6c2+ MNPs. In conclusion, nsPEF was a safe and effective treatment for liver cancer. The alteration of sphingolipid metabolism induced by nsPEF was associated with the differentiation of Ly6c2+ MNPs, and subsequently induced the formation of memory CD8+ T cells with potent antitumor effect." @default.
• W4313379829 created "2023-01-06" @default.
• W4313379829 creator A5000986776 @default.
• W4313379829 creator A5016874780 @default.
• W4313379829 creator A5018839528 @default.
• W4313379829 creator A5025283381 @default.
• W4313379829 creator A5029093676 @default.
• W4313379829 creator A5031359418 @default.
• W4313379829 creator A5036796352 @default.
• W4313379829 creator A5039927863 @default.
• W4313379829 creator A5067431012 @default.
• W4313379829 creator A5069088823 @default.
• W4313379829 creator A5079081217 @default.
• W4313379829 date "2023-01-21" @default.
• W4313379829 modified "2023-09-26" @default.
• W4313379829 title "Nanosecond pulsed electric field ablation‐induced modulation of sphingolipid metabolism is associated with <i>Ly6c2</i>⁺ mononuclear phagocyte differentiation in liver cancer" @default.
• W4313379829 cites W1649199697 @default.
• W4313379829 cites W1977540990 @default.
• W4313379829 cites W1984471249 @default.
• W4313379829 cites W1986156022 @default.
• W4313379829 cites W1996234730 @default.
• W4313379829 cites W2008995080 @default.
• W4313379829 cites W2014774747 @default.
• W4313379829 cites W2016406973 @default.
• W4313379829 cites W2019339732 @default.
• W4313379829 cites W2022287545 @default.
• W4313379829 cites W2024752083 @default.
• W4313379829 cites W2032154810 @default.
• W4313379829 cites W2036564362 @default.
• W4313379829 cites W2054828149 @default.
• W4313379829 cites W2055096275 @default.
• W4313379829 cites W2055573775 @default.
• W4313379829 cites W2071041149 @default.
• W4313379829 cites W2141606387 @default.
• W4313379829 cites W2146276289 @default.
• W4313379829 cites W2234453634 @default.
• W4313379829 cites W2321368314 @default.
• W4313379829 cites W2481838947 @default.
• W4313379829 cites W2514394434 @default.
• W4313379829 cites W2554914186 @default.
• W4313379829 cites W2607819139 @default.
• W4313379829 cites W2758096856 @default.
• W4313379829 cites W2773639323 @default.
• W4313379829 cites W2786818729 @default.
• W4313379829 cites W2790947248 @default.
• W4313379829 cites W2791209060 @default.
• W4313379829 cites W2892254103 @default.
• W4313379829 cites W2955063447 @default.
• W4313379829 cites W2969876915 @default.
• W4313379829 cites W3001095189 @default.
• W4313379829 cites W3048569636 @default.
• W4313379829 cites W3087129456 @default.
• W4313379829 cites W3088837230 @default.
• W4313379829 cites W3092359156 @default.
• W4313379829 cites W3106908673 @default.
• W4313379829 cites W3112241151 @default.
• W4313379829 cites W3112958688 @default.
• W4313379829 cites W3116009979 @default.
• W4313379829 cites W3126107065 @default.
• W4313379829 cites W3127415255 @default.
• W4313379829 cites W3135327518 @default.
• W4313379829 cites W3205843053 @default.
• W4313379829 cites W4210346363 @default.
• W4313379829 cites W4210782000 @default.
• W4313379829 cites W4246574809 @default.
• W4313379829 cites W4285087689 @default.
• W4313379829 cites W4293778116 @default.
• W4313379829 doi "https://doi.org/10.1002/1878-0261.13372" @default.
• W4313379829 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36587393" @default.
• W4313379829 hasPublicationYear "2023" @default.
• W4313379829 type Work @default.
• W4313379829 citedByCount "1" @default.
• W4313379829 countsByYear W43133798292023 @default.
• W4313379829 crossrefType "journal-article" @default.
• W4313379829 hasAuthorship W4313379829A5000986776 @default.
• W4313379829 hasAuthorship W4313379829A5016874780 @default.
• W4313379829 hasAuthorship W4313379829A5018839528 @default.
• W4313379829 hasAuthorship W4313379829A5025283381 @default.
• W4313379829 hasAuthorship W4313379829A5029093676 @default.
• W4313379829 hasAuthorship W4313379829A5031359418 @default.
• W4313379829 hasAuthorship W4313379829A5036796352 @default.
• W4313379829 hasAuthorship W4313379829A5039927863 @default.
• W4313379829 hasAuthorship W4313379829A5067431012 @default.
• W4313379829 hasAuthorship W4313379829A5069088823 @default.
• W4313379829 hasAuthorship W4313379829A5079081217 @default.
• W4313379829 hasBestOaLocation W43133798291 @default.
• W4313379829 hasConcept C121608353 @default.
• W4313379829 hasConcept C126322002 @default.
• W4313379829 hasConcept C137061746 @default.
• W4313379829 hasConcept C167672396 @default.
• W4313379829 hasConcept C185592680 @default.
• W4313379829 hasConcept C19702531 @default.
• W4313379829 hasConcept C202751555 @default.
• W4313379829 hasConcept C203014093 @default.
• W4313379829 hasConcept C2776231280 @default.
• W4313379829 hasConcept C2778019345 @default.
• W4313379829 hasConcept C2778902805 @default.
• W4313379829 hasConcept C502942594 @default.

• next