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- W4313379831 abstract "In recent years, polymorphic transformation involved in media milling has become a key factor in inducing the instability of nanosuspensions (NSs). The variation trend of microhydrodynamic parameters, including milling intensity factor (F), can be observed under different milling conditions. Therefore, this study first referenced the microhydrodynamic model to explore how formulations and process parameters affect Irbesartan (IRB) form A crystallinity during wet media milling. As a result, the crystallinity of form A was affected by the intermolecular interactions between drug particles and stabilizers. The crystallinity of form A decreased with decreasing drug loading, increasing stirrer speed and bead loading, which depended on the role of F. Milling could promote the transformation from a 1H to 2H tetrazole ring with stabilizers containing –OH, and form B was changed to form A and finally to an amorphous state. Molecular modelling shows that forms A and B are ductile and fragile materials, respectively, and both present anisotropy. When milling beads hit both polymorphs paralleling to the (0 1 0) surface, the bead-bead collisions are more helpful in fracturing IRB particles. The results of this study may provide a foundation for controlling crystal transformation and obtaining ideal crystal forms." @default.
- W4313379831 created "2023-01-06" @default.
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- W4313379831 date "2023-02-01" @default.
- W4313379831 modified "2023-09-27" @default.
- W4313379831 title "Elaborating the crystal transformation referenced microhydrodynamic model and fracture mechanism combined molecular modelling of irbesartan nanosuspensions formation in wet media milling" @default.
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- W4313379831 doi "https://doi.org/10.1016/j.ijpharm.2022.122562" @default.
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- W4313379831 hasPublicationYear "2023" @default.
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