Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313379880> ?p ?o ?g. }
- W4313379880 endingPage "109364" @default.
- W4313379880 startingPage "109364" @default.
- W4313379880 abstract "To determine the role of the cystine/glutamate antiporter on retinal structure and function, retinas of C57Bl/6J wild-type and xCT knockout mice, lacking the xCT subunit of the cystine/glutamate antiporter were examined from 6 weeks to 12 months of age. Fundoscopy, optical coherence tomography (OCT), and whole mount retinal autofluorescence imaging were used to visualise age-related retinal spots. Glial fibrillary acidic protein (GFAP) immunolabelling was used to assess retinal stress. Retinal function was evaluated using full-field and focal electroretinograms. Examinations revealed retinal spots in both wild-type and xCT knockout mice with the number of spots greater at 9 months in the knockout compared to wild-type. OCT confirmed these discrete spots were located at the retinal pigment epithelium (RPE)-photoreceptor junction and did not label with drusen markers. Whole mount lambda scans of the 9 month xCT knockout retinas revealed that the photoreceptor autofluorescence matched the spots, suggesting these spots were retinal debris. GFAP labelling was increased in knockout retinas compared to wild-type indicative of retinal stress, and the discrete spots were associated with migration of microglia/macrophages to the RPE-retina intersection. OCT revealed that the superior retina was thinner at 9 months in knockout compared to wild-type mice due to changes to the outer nuclear and photoreceptor layers. While global retinal function was not affected by loss of xCT, focal changes in retinal function were detected in areas where spots were present. Tother these results suggest that the xCT KO mice exhibit features of accelerated ageing and suggests that this mouse model may be useful for studying the underlying cellular pathways in retinal ageing." @default.
- W4313379880 created "2023-01-06" @default.
- W4313379880 creator A5003905457 @default.
- W4313379880 creator A5009213464 @default.
- W4313379880 creator A5009363652 @default.
- W4313379880 creator A5036731368 @default.
- W4313379880 creator A5050135304 @default.
- W4313379880 creator A5051587765 @default.
- W4313379880 creator A5064109772 @default.
- W4313379880 creator A5078076335 @default.
- W4313379880 date "2023-02-01" @default.
- W4313379880 modified "2023-09-25" @default.
- W4313379880 title "Early onset of age-related changes in the retina of cystine/glutamate antiporter knockout mice" @default.
- W4313379880 cites W1972864926 @default.
- W4313379880 cites W1975478432 @default.
- W4313379880 cites W1977286054 @default.
- W4313379880 cites W1978895733 @default.
- W4313379880 cites W1981968503 @default.
- W4313379880 cites W1984410770 @default.
- W4313379880 cites W1986510921 @default.
- W4313379880 cites W1987960089 @default.
- W4313379880 cites W1991234120 @default.
- W4313379880 cites W1996703105 @default.
- W4313379880 cites W2008591852 @default.
- W4313379880 cites W2020391754 @default.
- W4313379880 cites W2023333115 @default.
- W4313379880 cites W2028459637 @default.
- W4313379880 cites W2051176464 @default.
- W4313379880 cites W2055694741 @default.
- W4313379880 cites W2062005421 @default.
- W4313379880 cites W2067305246 @default.
- W4313379880 cites W2075901569 @default.
- W4313379880 cites W2084081191 @default.
- W4313379880 cites W2085222910 @default.
- W4313379880 cites W2089683931 @default.
- W4313379880 cites W2090115788 @default.
- W4313379880 cites W2097822945 @default.
- W4313379880 cites W2104301336 @default.
- W4313379880 cites W2109802152 @default.
- W4313379880 cites W2117429439 @default.
- W4313379880 cites W2126360899 @default.
- W4313379880 cites W2128961470 @default.
- W4313379880 cites W2133994038 @default.
- W4313379880 cites W2161467354 @default.
- W4313379880 cites W2329521208 @default.
- W4313379880 cites W2468879160 @default.
- W4313379880 cites W2481882640 @default.
- W4313379880 cites W2607445051 @default.
- W4313379880 cites W2743834900 @default.
- W4313379880 cites W2779838236 @default.
- W4313379880 cites W2806786818 @default.
- W4313379880 cites W2883601524 @default.
- W4313379880 cites W2888132367 @default.
- W4313379880 cites W2899668597 @default.
- W4313379880 cites W2982221081 @default.
- W4313379880 cites W3014843274 @default.
- W4313379880 cites W3093645662 @default.
- W4313379880 cites W3119618794 @default.
- W4313379880 cites W3177364048 @default.
- W4313379880 cites W3184238410 @default.
- W4313379880 doi "https://doi.org/10.1016/j.exer.2022.109364" @default.
- W4313379880 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36586548" @default.
- W4313379880 hasPublicationYear "2023" @default.
- W4313379880 type Work @default.
- W4313379880 citedByCount "0" @default.
- W4313379880 crossrefType "journal-article" @default.
- W4313379880 hasAuthorship W4313379880A5003905457 @default.
- W4313379880 hasAuthorship W4313379880A5009213464 @default.
- W4313379880 hasAuthorship W4313379880A5009363652 @default.
- W4313379880 hasAuthorship W4313379880A5036731368 @default.
- W4313379880 hasAuthorship W4313379880A5050135304 @default.
- W4313379880 hasAuthorship W4313379880A5051587765 @default.
- W4313379880 hasAuthorship W4313379880A5064109772 @default.
- W4313379880 hasAuthorship W4313379880A5078076335 @default.
- W4313379880 hasConcept C169760540 @default.
- W4313379880 hasConcept C170493617 @default.
- W4313379880 hasConcept C182704531 @default.
- W4313379880 hasConcept C185592680 @default.
- W4313379880 hasConcept C203014093 @default.
- W4313379880 hasConcept C204232928 @default.
- W4313379880 hasConcept C2777093970 @default.
- W4313379880 hasConcept C2778024200 @default.
- W4313379880 hasConcept C2780495277 @default.
- W4313379880 hasConcept C2780827179 @default.
- W4313379880 hasConcept C55493867 @default.
- W4313379880 hasConcept C86803240 @default.
- W4313379880 hasConcept C95444343 @default.
- W4313379880 hasConceptScore W4313379880C169760540 @default.
- W4313379880 hasConceptScore W4313379880C170493617 @default.
- W4313379880 hasConceptScore W4313379880C182704531 @default.
- W4313379880 hasConceptScore W4313379880C185592680 @default.
- W4313379880 hasConceptScore W4313379880C203014093 @default.
- W4313379880 hasConceptScore W4313379880C204232928 @default.
- W4313379880 hasConceptScore W4313379880C2777093970 @default.
- W4313379880 hasConceptScore W4313379880C2778024200 @default.
- W4313379880 hasConceptScore W4313379880C2780495277 @default.
- W4313379880 hasConceptScore W4313379880C2780827179 @default.
- W4313379880 hasConceptScore W4313379880C55493867 @default.