FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313379894> ?p ?o ?g. }

• W4313379894 endingPage "154221" @default.
• W4313379894 startingPage "154221" @default.
• W4313379894 abstract "To identify phenotypes of Intensive Care Unit (ICU) onset sepsis and its associated harms of delayed time-to-antibiotics. The Medical Information Mart for Intensive Care IV (MIMIC-IV) database was employed to identify patients with ICU onset sepsis. The primary exposure was time-to-antibiotics, as measured from sepsis recognition to first antibiotic administered. Latent profile analysis (LPA) was used to identify phenotypes of sepsis based on individual organ failure score derived from Sequential Organ Failure Assessment (SOFA). Interactions between phenotypes and time-to-antibiotics on 28-day mortality were explored. 6246 patients were enrolled in final analysis. The overall 28-day mortality was 12.7%. Delayed time-to-antibiotics was associated with increased 28-day mortality in patients with ICU onset sepsis (HR 1.12, 95% CI 1.08–1.18). Four phenotypes of sepsis were identified: phenotype 1 was characterized by respiratory dysfunction, phenotype 2 was characterized by cardiovascular dysfunction, phenotype 3 was characterized by multiple organ dysfunction, and phenotype 4 was characterized by neurological dysfunction. The adjusted HR of 28-day mortality was 1.16 (95% CI 1.08–1.25) in phenotype 1, and 1.06 (95% CI 1.00–1.13) in phenotype 2, while no significant interaction was observed. Septic patients with respiratory or cardiovascular dysfunction were associated with harms of delayed time-to-antibiotics." @default.
• W4313379894 created "2023-01-06" @default.
• W4313379894 creator A5001046267 @default.
• W4313379894 creator A5002777768 @default.
• W4313379894 creator A5009218034 @default.
• W4313379894 creator A5011090841 @default.
• W4313379894 creator A5014664356 @default.
• W4313379894 creator A5028636632 @default.
• W4313379894 creator A5040058951 @default.
• W4313379894 creator A5053780153 @default.
• W4313379894 creator A5074472303 @default.
• W4313379894 creator A5082666219 @default.
• W4313379894 creator A5083944681 @default.
• W4313379894 creator A5084410970 @default.
• W4313379894 date "2023-04-01" @default.
• W4313379894 modified "2023-09-30" @default.
• W4313379894 title "Identifying high-risk phenotypes and associated harms of delayed time-to-antibiotics in patients with ICU onset sepsis: A retrospective cohort study" @default.
• W4313379894 cites W1974155313 @default.
• W4313379894 cites W2016741997 @default.
• W4313379894 cites W2027831139 @default.
• W4313379894 cites W2090330784 @default.
• W4313379894 cites W2144589352 @default.
• W4313379894 cites W2149448199 @default.
• W4313379894 cites W2151646746 @default.
• W4313379894 cites W2163278718 @default.
• W4313379894 cites W2280404143 @default.
• W4313379894 cites W2572590842 @default.
• W4313379894 cites W2599245417 @default.
• W4313379894 cites W2614741637 @default.
• W4313379894 cites W2770291148 @default.
• W4313379894 cites W2776803885 @default.
• W4313379894 cites W2782502282 @default.
• W4313379894 cites W2792583887 @default.
• W4313379894 cites W2904677804 @default.
• W4313379894 cites W2912904466 @default.
• W4313379894 cites W2944988359 @default.
• W4313379894 cites W2950811882 @default.
• W4313379894 cites W2990895485 @default.
• W4313379894 cites W2994455367 @default.
• W4313379894 cites W2995282027 @default.
• W4313379894 cites W3036684707 @default.
• W4313379894 cites W3048074762 @default.
• W4313379894 cites W3081682404 @default.
• W4313379894 cites W3130251731 @default.
• W4313379894 cites W3158146273 @default.
• W4313379894 cites W3165531139 @default.
• W4313379894 cites W3174062674 @default.
• W4313379894 cites W3189244054 @default.
• W4313379894 cites W3202964273 @default.
• W4313379894 cites W4225565706 @default.
• W4313379894 cites W4280556240 @default.
• W4313379894 doi "https://doi.org/10.1016/j.jcrc.2022.154221" @default.
• W4313379894 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36565649" @default.
• W4313379894 hasPublicationYear "2023" @default.
• W4313379894 type Work @default.
• W4313379894 citedByCount "2" @default.
• W4313379894 countsByYear W43133798942023 @default.
• W4313379894 crossrefType "journal-article" @default.
• W4313379894 hasAuthorship W4313379894A5001046267 @default.
• W4313379894 hasAuthorship W4313379894A5002777768 @default.
• W4313379894 hasAuthorship W4313379894A5009218034 @default.
• W4313379894 hasAuthorship W4313379894A5011090841 @default.
• W4313379894 hasAuthorship W4313379894A5014664356 @default.
• W4313379894 hasAuthorship W4313379894A5028636632 @default.
• W4313379894 hasAuthorship W4313379894A5040058951 @default.
• W4313379894 hasAuthorship W4313379894A5053780153 @default.
• W4313379894 hasAuthorship W4313379894A5074472303 @default.
• W4313379894 hasAuthorship W4313379894A5082666219 @default.
• W4313379894 hasAuthorship W4313379894A5083944681 @default.
• W4313379894 hasAuthorship W4313379894A5084410970 @default.
• W4313379894 hasConcept C104317684 @default.
• W4313379894 hasConcept C126322002 @default.
• W4313379894 hasConcept C127716648 @default.
• W4313379894 hasConcept C177713679 @default.
• W4313379894 hasConcept C2776376669 @default.
• W4313379894 hasConcept C2777465075 @default.
• W4313379894 hasConcept C2778384902 @default.
• W4313379894 hasConcept C2778426790 @default.
• W4313379894 hasConcept C2987404301 @default.
• W4313379894 hasConcept C501593827 @default.
• W4313379894 hasConcept C55493867 @default.
• W4313379894 hasConcept C71924100 @default.
• W4313379894 hasConcept C72563966 @default.
• W4313379894 hasConcept C86803240 @default.
• W4313379894 hasConcept C89423630 @default.
• W4313379894 hasConceptScore W4313379894C104317684 @default.
• W4313379894 hasConceptScore W4313379894C126322002 @default.
• W4313379894 hasConceptScore W4313379894C127716648 @default.
• W4313379894 hasConceptScore W4313379894C177713679 @default.
• W4313379894 hasConceptScore W4313379894C2776376669 @default.
• W4313379894 hasConceptScore W4313379894C2777465075 @default.
• W4313379894 hasConceptScore W4313379894C2778384902 @default.
• W4313379894 hasConceptScore W4313379894C2778426790 @default.
• W4313379894 hasConceptScore W4313379894C2987404301 @default.
• W4313379894 hasConceptScore W4313379894C501593827 @default.
• W4313379894 hasConceptScore W4313379894C55493867 @default.
• W4313379894 hasConceptScore W4313379894C71924100 @default.
• W4313379894 hasConceptScore W4313379894C72563966 @default.

• next