FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313379918> ?p ?o ?g. }

• W4313379918 endingPage "626" @default.
• W4313379918 startingPage "617" @default.
• W4313379918 abstract "The optimal management of early-stage, low-risk, hormone-positive breast cancer in older women remains controversial. Recent trials have shown that 5-fraction ultrahypofractionated whole-breast irradiation (U-WBI) has similar outcomes to longer courses, reducing the cost and inconvenience of treatment. We performed a cost-utility analysis to compare U-WBI to hormone therapy alone or their combination.We simulated 3 different treatment approaches for women age 65 years or older with pT1-2N0 ER-positive invasive ductal carcinoma treated with lumpectomy with negative margins using a Markov microsimulation model. The strategies were U-WBI performed with a 3-dimensional conformal technique over 5 fractions without a boost (radiation therapy [RT] alone), adjuvant hormone therapy (anastrozole for 5 years) without RT (aromatase-inhibitor [AI] alone), or the combination of the 2. The combination strategy was calibrated to match trial results, and the relative effectiveness of the RT alone and AI alone strategies were inferred from previous randomized trials. The primary endpoint was the cost-effectiveness of the 3 strategies over a lifetime horizon as measured by the incremental cost-effectiveness ratio (ICER), with a value of $100,000/quality-adjusted life-year deemed cost-effective.The model results compared with the prespecified target outcomes. On average, RT alone was the least expensive strategy ($14,775), with AI alone slightly more ($14,998), and combination therapy the costliest ($19,802). RT alone dominated AI alone (the incremental cost-effectiveness ratio [ICER] -$5089). Combination therapy, compared with RT alone, was slightly more expensive than our definition of cost-effective (ICER $113,468) but was cost-effective compared with AI alone (ICER $54,451). Probabilistic sensitivity analysis demonstrated RT alone to be cost-effective in 50% of trials, with combination therapy in 36% and AI alone in 14%.U-WBI alone appears the more cost-effective de-escalation strategy for these low-risk patients, compared with AI alone. Combining U-WBI and AI appears more costly but may be preferred by some patients." @default.
• W4313379918 created "2023-01-06" @default.
• W4313379918 creator A5013474509 @default.
• W4313379918 creator A5014570917 @default.
• W4313379918 creator A5016407136 @default.
• W4313379918 creator A5019431185 @default.
• W4313379918 creator A5034562811 @default.
• W4313379918 creator A5038579531 @default.
• W4313379918 creator A5049384427 @default.
• W4313379918 creator A5060079446 @default.
• W4313379918 creator A5063250950 @default.
• W4313379918 creator A5064398705 @default.
• W4313379918 creator A5090501436 @default.
• W4313379918 date "2023-07-01" @default.
• W4313379918 modified "2023-10-16" @default.
• W4313379918 title "Cost-Effectiveness Analysis of Ultra-Hypofractionated Whole Breast Radiation Therapy Alone Versus Hormone Therapy Alone or Combined Treatment for Low-Risk ER-Positive Early Stage Breast Cancer in Women Aged 65 Years and Older" @default.
• W4313379918 cites W1512462479 @default.
• W4313379918 cites W1558732244 @default.
• W4313379918 cites W1728715977 @default.
• W4313379918 cites W1861968279 @default.
• W4313379918 cites W189716308 @default.
• W4313379918 cites W1936813410 @default.
• W4313379918 cites W1964637210 @default.
• W4313379918 cites W1969229373 @default.
• W4313379918 cites W1969786284 @default.
• W4313379918 cites W1982853521 @default.
• W4313379918 cites W1983463961 @default.
• W4313379918 cites W1985687068 @default.
• W4313379918 cites W1989362621 @default.
• W4313379918 cites W1990582579 @default.
• W4313379918 cites W1993904396 @default.
• W4313379918 cites W1998066321 @default.
• W4313379918 cites W2002026603 @default.
• W4313379918 cites W200263122 @default.
• W4313379918 cites W2021914207 @default.
• W4313379918 cites W2024658919 @default.
• W4313379918 cites W2040593396 @default.
• W4313379918 cites W2043468165 @default.
• W4313379918 cites W2044658894 @default.
• W4313379918 cites W2050254987 @default.
• W4313379918 cites W2058621175 @default.
• W4313379918 cites W2064936613 @default.
• W4313379918 cites W2067254496 @default.
• W4313379918 cites W2067420088 @default.
• W4313379918 cites W2084066572 @default.
• W4313379918 cites W2100025800 @default.
• W4313379918 cites W2100787775 @default.
• W4313379918 cites W2104793011 @default.
• W4313379918 cites W2108995265 @default.
• W4313379918 cites W2118728607 @default.
• W4313379918 cites W2121656289 @default.
• W4313379918 cites W2122428334 @default.
• W4313379918 cites W2128585633 @default.
• W4313379918 cites W2137411979 @default.
• W4313379918 cites W2138163136 @default.
• W4313379918 cites W2143025931 @default.
• W4313379918 cites W2144133819 @default.
• W4313379918 cites W2144145638 @default.
• W4313379918 cites W2144714162 @default.
• W4313379918 cites W2144887315 @default.
• W4313379918 cites W2149455283 @default.
• W4313379918 cites W2152969899 @default.
• W4313379918 cites W2163322699 @default.
• W4313379918 cites W2171799844 @default.
• W4313379918 cites W2172198909 @default.
• W4313379918 cites W2191470295 @default.
• W4313379918 cites W2211631799 @default.
• W4313379918 cites W2214665719 @default.
• W4313379918 cites W2314244786 @default.
• W4313379918 cites W2366835925 @default.
• W4313379918 cites W2395258407 @default.
• W4313379918 cites W2409054761 @default.
• W4313379918 cites W2417921421 @default.
• W4313379918 cites W2558360748 @default.
• W4313379918 cites W2596883961 @default.
• W4313379918 cites W2620389466 @default.
• W4313379918 cites W2767499950 @default.
• W4313379918 cites W2771117067 @default.
• W4313379918 cites W2782941313 @default.
• W4313379918 cites W2789698864 @default.
• W4313379918 cites W2893360496 @default.
• W4313379918 cites W2952817283 @default.
• W4313379918 cites W2979784793 @default.
• W4313379918 cites W2993667428 @default.
• W4313379918 cites W3005655675 @default.
• W4313379918 cites W3016251265 @default.
• W4313379918 cites W3022548009 @default.
• W4313379918 cites W3031623342 @default.
• W4313379918 cites W3045897492 @default.
• W4313379918 cites W3121106711 @default.
• W4313379918 cites W3129239981 @default.
• W4313379918 cites W3161923587 @default.
• W4313379918 cites W4206953994 @default.
• W4313379918 doi "https://doi.org/10.1016/j.ijrobp.2022.12.028" @default.
• W4313379918 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36586492" @default.
• W4313379918 hasPublicationYear "2023" @default.
• W4313379918 type Work @default.
• W4313379918 citedByCount "2" @default.

• next