Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313379939> ?p ?o ?g. }
- W4313379939 endingPage "100864" @default.
- W4313379939 startingPage "100864" @default.
- W4313379939 abstract "The underlying mechanism for radiation as a potentiator of immune checkpoint inhibition (ICI) is unclear. We developed a novel murine model to investigate the effects of post-irradiation intratumoral heterogeneity (ITH) on response to ICI.Parental mouse melanoma B16F10 cells were irradiated in vitro (5Gy x 3 fractions), then an a priori determined number of resulting colonies were implanted in C57BL/6J immunocompetent mice creating syngeneic models of unirradiated (parental) and irradiated tumors with low (irradiated-L) and high (irradiated-H) ITH. Mice were treated with placebo, α-PD-L1, α-CTLA-4 or dual ICI. Murine tumors underwent whole exome sequencing (WES). Clinically correlated paired pre- and post-irradiation patient rectal adenocarcinoma samples underwent WES.Irradiated-L tumors showed increased tumor mutational burden (TMB) and a sustained decrease in ITH. Irradiated-L tumors were predicted to express five neoantigens with high variant allele frequency/clonal distribution. Mice with irradiated-L and irradiated-H versus parental B16F10 tumors demonstrated longer overall survival with dual ICI. Only mice with irradiated-L tumors experienced an overall survival benefit with single agent ICI. Clinically correlated rectal adenocarcinoma samples showed similarly increased TMB and decreased ITH following irradiation.Post-irradiation ITH modulates ICI response in a murine melanoma model. Irradiation may offer a mechanism to widen the therapeutic window of ICI." @default.
- W4313379939 created "2023-01-06" @default.
- W4313379939 creator A5013412405 @default.
- W4313379939 creator A5021642943 @default.
- W4313379939 creator A5025392552 @default.
- W4313379939 creator A5033510051 @default.
- W4313379939 creator A5041411617 @default.
- W4313379939 creator A5043168888 @default.
- W4313379939 creator A5051787316 @default.
- W4313379939 creator A5057233464 @default.
- W4313379939 creator A5075877965 @default.
- W4313379939 creator A5078419652 @default.
- W4313379939 creator A5078712054 @default.
- W4313379939 creator A5082446850 @default.
- W4313379939 creator A5091580880 @default.
- W4313379939 date "2023-02-01" @default.
- W4313379939 modified "2023-10-15" @default.
- W4313379939 title "Post-irradiation intratumoral heterogeneity modulates response to immune checkpoint inhibition therapy in a murine melanoma model" @default.
- W4313379939 cites W1897491859 @default.
- W4313379939 cites W1912124796 @default.
- W4313379939 cites W1940241680 @default.
- W4313379939 cites W1984068087 @default.
- W4313379939 cites W1999574084 @default.
- W4313379939 cites W2049553585 @default.
- W4313379939 cites W2075879891 @default.
- W4313379939 cites W2096064375 @default.
- W4313379939 cites W2100928937 @default.
- W4313379939 cites W2104885590 @default.
- W4313379939 cites W2107429737 @default.
- W4313379939 cites W2117878645 @default.
- W4313379939 cites W2121743948 @default.
- W4313379939 cites W2124649657 @default.
- W4313379939 cites W2138601221 @default.
- W4313379939 cites W2150575159 @default.
- W4313379939 cites W2169456326 @default.
- W4313379939 cites W2182664595 @default.
- W4313379939 cites W2219761119 @default.
- W4313379939 cites W2256496883 @default.
- W4313379939 cites W2260951263 @default.
- W4313379939 cites W2291298003 @default.
- W4313379939 cites W2417483443 @default.
- W4313379939 cites W2551783467 @default.
- W4313379939 cites W2566833162 @default.
- W4313379939 cites W2618641368 @default.
- W4313379939 cites W2622499649 @default.
- W4313379939 cites W2747774814 @default.
- W4313379939 cites W2752441830 @default.
- W4313379939 cites W2770095154 @default.
- W4313379939 cites W2797675588 @default.
- W4313379939 cites W2806383117 @default.
- W4313379939 cites W2883000607 @default.
- W4313379939 cites W2898394368 @default.
- W4313379939 cites W2942698526 @default.
- W4313379939 cites W2943781197 @default.
- W4313379939 cites W2972939290 @default.
- W4313379939 cites W2980537150 @default.
- W4313379939 cites W2980875266 @default.
- W4313379939 cites W2991341799 @default.
- W4313379939 cites W2995313504 @default.
- W4313379939 cites W3020551799 @default.
- W4313379939 cites W3093708469 @default.
- W4313379939 cites W3094422108 @default.
- W4313379939 cites W3125240514 @default.
- W4313379939 cites W3139900359 @default.
- W4313379939 cites W3168094540 @default.
- W4313379939 cites W4247053599 @default.
- W4313379939 doi "https://doi.org/10.1016/j.neo.2022.100864" @default.
- W4313379939 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36571944" @default.
- W4313379939 hasPublicationYear "2023" @default.
- W4313379939 type Work @default.
- W4313379939 citedByCount "0" @default.
- W4313379939 crossrefType "journal-article" @default.
- W4313379939 hasAuthorship W4313379939A5013412405 @default.
- W4313379939 hasAuthorship W4313379939A5021642943 @default.
- W4313379939 hasAuthorship W4313379939A5025392552 @default.
- W4313379939 hasAuthorship W4313379939A5033510051 @default.
- W4313379939 hasAuthorship W4313379939A5041411617 @default.
- W4313379939 hasAuthorship W4313379939A5043168888 @default.
- W4313379939 hasAuthorship W4313379939A5051787316 @default.
- W4313379939 hasAuthorship W4313379939A5057233464 @default.
- W4313379939 hasAuthorship W4313379939A5075877965 @default.
- W4313379939 hasAuthorship W4313379939A5078419652 @default.
- W4313379939 hasAuthorship W4313379939A5078712054 @default.
- W4313379939 hasAuthorship W4313379939A5082446850 @default.
- W4313379939 hasAuthorship W4313379939A5091580880 @default.
- W4313379939 hasBestOaLocation W43133799391 @default.
- W4313379939 hasConcept C111337013 @default.
- W4313379939 hasConcept C121332964 @default.
- W4313379939 hasConcept C121608353 @default.
- W4313379939 hasConcept C126322002 @default.
- W4313379939 hasConcept C185544564 @default.
- W4313379939 hasConcept C203014093 @default.
- W4313379939 hasConcept C207001950 @default.
- W4313379939 hasConcept C2777658100 @default.
- W4313379939 hasConcept C2777701055 @default.
- W4313379939 hasConcept C2780851360 @default.
- W4313379939 hasConcept C2781182431 @default.
- W4313379939 hasConcept C502942594 @default.