FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313379962> ?p ?o ?g. }

• W4313379962 endingPage "114314" @default.
• W4313379962 startingPage "114314" @default.
• W4313379962 abstract "Functional reconstruction after peripheral nerve injury depends on the ability of the regenerated sensory and motor axons to re-innervate the suitable target organs. Therefore, it is essential to explore the cellular mechanisms of peripheral nerve-specific regeneration. In a previous study, we found that sensory and motor fibroblasts can guide Schwann cells to migrate towards the same phenotype. In the present paper, we analyzed the different effects of sensory and motor fibroblasts on sensory or motor neurons. The fibroblasts and neurons co-culture assay showed that compared with motor fibroblasts, sensory fibroblasts promote the neurite outgrowth of sensory neurons on a larger scale, and vice versa. Furthermore, a higher proportion of sensory or motor fibroblasts migrated towards their respective (sensory or motor) neurons. Meanwhile, a comparative proteomic approach was applied to obtain the protein expression profiles of sensory and motor fibroblasts. Among a total of 2597 overlapping proteins identified, we counted 148 differentially expressed items, of those 116 had a significantly higher expression in sensory fibroblasts, and 32 had a significantly greater expression in motor fibroblasts. Functional categorization revealed that differentially expressed proteins were involved in regeneration, axon guidance and cytoskeleton organization, all of which might play a critical role in peripheral nerve-specific regeneration. After nerve crush injury, ITB1 protein expression decreased significantly in motor nerves and increased in sensory nerves. In vitro, ITB1 significantly promoted axonal regeneration of sensory neurons, but had no significant effect on motor neurons. Overall, sensory and motor fibroblasts express different proteins and exert different growth promoting effects on sensory and motor neurons. This comparative proteomic database of sensory and motor fibroblasts could provide future directions for in-depth research on peripheral nerve-specific regeneration. Data are available via ProteomeXchange with identifier PXD034827." @default.
• W4313379962 created "2023-01-06" @default.
• W4313379962 creator A5016051561 @default.
• W4313379962 creator A5025961615 @default.
• W4313379962 creator A5038805449 @default.
• W4313379962 creator A5043878079 @default.
• W4313379962 creator A5066018914 @default.
• W4313379962 creator A5066219408 @default.
• W4313379962 creator A5066680855 @default.
• W4313379962 creator A5075300495 @default.
• W4313379962 creator A5091037202 @default.
• W4313379962 date "2023-03-01" @default.
• W4313379962 modified "2023-09-27" @default.
• W4313379962 title "Sensory and motor fibroblasts have different protein expression patterns and exert different growth promoting effects on sensory and motor neurons" @default.
• W4313379962 cites W1856059914 @default.
• W4313379962 cites W1873112233 @default.
• W4313379962 cites W1975518740 @default.
• W4313379962 cites W1976328687 @default.
• W4313379962 cites W1989369048 @default.
• W4313379962 cites W1989815000 @default.
• W4313379962 cites W1997647174 @default.
• W4313379962 cites W2019602403 @default.
• W4313379962 cites W2044911441 @default.
• W4313379962 cites W2050935187 @default.
• W4313379962 cites W2079800084 @default.
• W4313379962 cites W2089956752 @default.
• W4313379962 cites W2105787434 @default.
• W4313379962 cites W2345128728 @default.
• W4313379962 cites W2548933759 @default.
• W4313379962 cites W2562689558 @default.
• W4313379962 cites W2771307807 @default.
• W4313379962 cites W2909068371 @default.
• W4313379962 cites W2974470952 @default.
• W4313379962 cites W3082622650 @default.
• W4313379962 cites W3087451884 @default.
• W4313379962 cites W3093068333 @default.
• W4313379962 cites W3111210995 @default.
• W4313379962 cites W4200095869 @default.
• W4313379962 cites W4284887999 @default.
• W4313379962 cites W4295745140 @default.
• W4313379962 doi "https://doi.org/10.1016/j.expneurol.2022.114314" @default.
• W4313379962 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36586550" @default.
• W4313379962 hasPublicationYear "2023" @default.
• W4313379962 type Work @default.
• W4313379962 citedByCount "0" @default.
• W4313379962 crossrefType "journal-article" @default.
• W4313379962 hasAuthorship W4313379962A5016051561 @default.
• W4313379962 hasAuthorship W4313379962A5025961615 @default.
• W4313379962 hasAuthorship W4313379962A5038805449 @default.
• W4313379962 hasAuthorship W4313379962A5043878079 @default.
• W4313379962 hasAuthorship W4313379962A5066018914 @default.
• W4313379962 hasAuthorship W4313379962A5066219408 @default.
• W4313379962 hasAuthorship W4313379962A5066680855 @default.
• W4313379962 hasAuthorship W4313379962A5075300495 @default.
• W4313379962 hasAuthorship W4313379962A5091037202 @default.
• W4313379962 hasConcept C113246987 @default.
• W4313379962 hasConcept C169760540 @default.
• W4313379962 hasConcept C171056886 @default.
• W4313379962 hasConcept C202751555 @default.
• W4313379962 hasConcept C2775907655 @default.
• W4313379962 hasConcept C2775908076 @default.
• W4313379962 hasConcept C2776752467 @default.
• W4313379962 hasConcept C2779530196 @default.
• W4313379962 hasConcept C2780775167 @default.
• W4313379962 hasConcept C55493867 @default.
• W4313379962 hasConcept C86803240 @default.
• W4313379962 hasConcept C94487597 @default.
• W4313379962 hasConcept C95444343 @default.
• W4313379962 hasConceptScore W4313379962C113246987 @default.
• W4313379962 hasConceptScore W4313379962C169760540 @default.
• W4313379962 hasConceptScore W4313379962C171056886 @default.
• W4313379962 hasConceptScore W4313379962C202751555 @default.
• W4313379962 hasConceptScore W4313379962C2775907655 @default.
• W4313379962 hasConceptScore W4313379962C2775908076 @default.
• W4313379962 hasConceptScore W4313379962C2776752467 @default.
• W4313379962 hasConceptScore W4313379962C2779530196 @default.
• W4313379962 hasConceptScore W4313379962C2780775167 @default.
• W4313379962 hasConceptScore W4313379962C55493867 @default.
• W4313379962 hasConceptScore W4313379962C86803240 @default.
• W4313379962 hasConceptScore W4313379962C94487597 @default.
• W4313379962 hasConceptScore W4313379962C95444343 @default.
• W4313379962 hasLocation W43133799621 @default.
• W4313379962 hasLocation W43133799622 @default.
• W4313379962 hasOpenAccess W4313379962 @default.
• W4313379962 hasPrimaryLocation W43133799621 @default.
• W4313379962 hasRelatedWork W2003382110 @default.
• W4313379962 hasRelatedWork W2032367884 @default.
• W4313379962 hasRelatedWork W2034685321 @default.
• W4313379962 hasRelatedWork W2051525285 @default.
• W4313379962 hasRelatedWork W2086698699 @default.
• W4313379962 hasRelatedWork W2087879757 @default.
• W4313379962 hasRelatedWork W2791333980 @default.
• W4313379962 hasRelatedWork W2919402206 @default.
• W4313379962 hasRelatedWork W4291134809 @default.
• W4313379962 hasRelatedWork W4313379962 @default.
• W4313379962 hasVolume "361" @default.
• W4313379962 isParatext "false" @default.
• W4313379962 isRetracted "false" @default.

• next