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- W4313381144 startingPage "219.2" @default.
- W4313381144 abstract "Abstract Primary biliary cirrhosis (PBC) is an autoimmune disease which is characterized by bile duct injuries result from excessive immune responses. In female over the age of 40, the incidence of PBC has been estimated to be one out of 1000 people. Liver transplantation is required for patients who progress to end-stage PBC. However, risk factors and causes of PBC remain elusive. We performed whole-exome sequencing in a family with four sisters diagnosed with PBC and one healthy half-sister. Additionally, Sanger sequencing was conducted with 62 unrelated PBC patient specimens. Here, we identified a potential PBC causative gene factor Y, a regulator of cell death and inflammation. We investigated whether factor Y plays a role in PBC using factor Y null human macrophage cell line generated by CRIPSR/Cas9 technology. We found ablation of factor Y induces inflammatory cytokines compared with control cells upon treatment with LPS or TNF. Surprisingly, molecules secreted by factor Y null cell line induced fibrosis in human hepatic stellate cell, LX-2. These results indicate that factor Y is a potential target for treatment of PBC." @default.
- W4313381144 created "2023-01-06" @default.
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- W4313381144 date "2020-05-01" @default.
- W4313381144 modified "2023-10-16" @default.
- W4313381144 title "The role of factor Y in primary biliary cirrhosis" @default.
- W4313381144 doi "https://doi.org/10.4049/jimmunol.204.supp.219.2" @default.
- W4313381144 hasPublicationYear "2020" @default.
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