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- W4313381172 abstract "Abstract Treatment with glucocorticoid-induced tumor necrosis factor receptor-related protein (GITR) agonistic antibody (DTA-1) elicits potent antitumor immune responses in various tumor models. In this study, we demonstrate the crucial role of interleukin (IL)-21–producing follicular helper T (Tfh) cells in DTA-1-induced tumor inhibition. Administration of DTA-1 increased IL-21 expression from CD4 T cells, which is mainly made up of Tfh cells, in an antigen specific manner. Furthermore, mice treated with a neutralizing antibody to IL-21 receptor and Bcl6fl/flCD4cre mice exhibited abrogated antitumor activity induced by DTA-1. Mechanistically, IL-4 plays critical roles for the induction of IL-21–expressing Th cells by GITR co-stimulation, which is mediated by Bcl6 and c-Maf. Thus, our findings identify GITR co-stimulation as an inducer of IL-21–expressing Tfh cells and provide a novel mechanism for its antitumor activity." @default.
- W4313381172 created "2023-01-06" @default.
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- W4313381172 date "2019-05-01" @default.
- W4313381172 modified "2023-10-18" @default.
- W4313381172 title "GITR agonism triggers antitumor immune responses through IL-21–expressing follicular helper T cells" @default.
- W4313381172 doi "https://doi.org/10.4049/jimmunol.202.supp.195.15" @default.
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