Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313381381> ?p ?o ?g. }
Showing items 1 to 80 of
80
with 100 items per page.
- W4313381381 endingPage "194.38" @default.
- W4313381381 startingPage "194.38" @default.
- W4313381381 abstract "Abstract Anti-CD47 antibodies have been shown to inhibit the progression of several types of cancer by blocking the “don’t eat me” signals to macrophage through CD47/SIRPα interaction, causing phagocytosis of tumor cell. However, mechanistic details in the response of the cancer cells still remain to be explored. In this study, we investigated different cytokine levels in 4T1 mammary carcinoma induced mouse breast cancer model with or without anti-mouse CD47 monoclonal antibody treatment. The data showed that this cancer model presented significantly higher percentages of CD11b+, CD43+, CD80+, CD86+ and CD371+ cells after 1 week of 4T1 cells injection, CD11b+ cells percentage has been reached to 40% and 90% in spleen and bone marrow respectively at 2 weeks after 4T1 cells injection. After 4 doses of anti-mouse CD47 antibody treatment (i.p. injection per 2 days started from one week after 4T1 challenge), anti-CD47 antibody reduced significantly not only tumor size but also the levels of IL-1α in spleen (P=0.026) and of MCP-1/CCL2 in tumors (P=0.029). Interestingly, fresh isolated 4T1 induced breast cancer mouse spleen and bone marrow cells appeared 5%-10% CD11b+/Sca-1+ populations whereas in vitro culture of 4T1 cells had 5% of cells of Sca-1+/CD326+. When the freshly isolated 4T1 induced breast cancer mouse spleen and bone marrow cells were continuously cultured for 2–3 weeks, CD326+ cells became dominant and about 10% – 30% of population showed Sca-1+/CD11b+ positive. This study provided inside thoroughly investigated the response of cytokines and 4T1 cells induced mouse mammary carcinoma. Our data may further discover the mechanism for tumor growth and metastasis." @default.
- W4313381381 created "2023-01-06" @default.
- W4313381381 creator A5019208828 @default.
- W4313381381 creator A5061770956 @default.
- W4313381381 creator A5069849278 @default.
- W4313381381 creator A5074350801 @default.
- W4313381381 creator A5081732807 @default.
- W4313381381 creator A5088193606 @default.
- W4313381381 creator A5091257281 @default.
- W4313381381 date "2019-05-01" @default.
- W4313381381 modified "2023-09-25" @default.
- W4313381381 title "Immune cell phenotype and cytokine secretion in mouse breast cancer responding to anti-CD47 antibody treatment" @default.
- W4313381381 doi "https://doi.org/10.4049/jimmunol.202.supp.194.38" @default.
- W4313381381 hasPublicationYear "2019" @default.
- W4313381381 type Work @default.
- W4313381381 citedByCount "0" @default.
- W4313381381 crossrefType "journal-article" @default.
- W4313381381 hasAuthorship W4313381381A5019208828 @default.
- W4313381381 hasAuthorship W4313381381A5061770956 @default.
- W4313381381 hasAuthorship W4313381381A5069849278 @default.
- W4313381381 hasAuthorship W4313381381A5074350801 @default.
- W4313381381 hasAuthorship W4313381381A5081732807 @default.
- W4313381381 hasAuthorship W4313381381A5088193606 @default.
- W4313381381 hasAuthorship W4313381381A5091257281 @default.
- W4313381381 hasConcept C121608353 @default.
- W4313381381 hasConcept C126322002 @default.
- W4313381381 hasConcept C154317977 @default.
- W4313381381 hasConcept C159654299 @default.
- W4313381381 hasConcept C202751555 @default.
- W4313381381 hasConcept C203014093 @default.
- W4313381381 hasConcept C2778690821 @default.
- W4313381381 hasConcept C2780007613 @default.
- W4313381381 hasConcept C2780104668 @default.
- W4313381381 hasConcept C2780931953 @default.
- W4313381381 hasConcept C39347974 @default.
- W4313381381 hasConcept C502942594 @default.
- W4313381381 hasConcept C530470458 @default.
- W4313381381 hasConcept C55493867 @default.
- W4313381381 hasConcept C71924100 @default.
- W4313381381 hasConcept C86803240 @default.
- W4313381381 hasConcept C8891405 @default.
- W4313381381 hasConcept C96232424 @default.
- W4313381381 hasConceptScore W4313381381C121608353 @default.
- W4313381381 hasConceptScore W4313381381C126322002 @default.
- W4313381381 hasConceptScore W4313381381C154317977 @default.
- W4313381381 hasConceptScore W4313381381C159654299 @default.
- W4313381381 hasConceptScore W4313381381C202751555 @default.
- W4313381381 hasConceptScore W4313381381C203014093 @default.
- W4313381381 hasConceptScore W4313381381C2778690821 @default.
- W4313381381 hasConceptScore W4313381381C2780007613 @default.
- W4313381381 hasConceptScore W4313381381C2780104668 @default.
- W4313381381 hasConceptScore W4313381381C2780931953 @default.
- W4313381381 hasConceptScore W4313381381C39347974 @default.
- W4313381381 hasConceptScore W4313381381C502942594 @default.
- W4313381381 hasConceptScore W4313381381C530470458 @default.
- W4313381381 hasConceptScore W4313381381C55493867 @default.
- W4313381381 hasConceptScore W4313381381C71924100 @default.
- W4313381381 hasConceptScore W4313381381C86803240 @default.
- W4313381381 hasConceptScore W4313381381C8891405 @default.
- W4313381381 hasConceptScore W4313381381C96232424 @default.
- W4313381381 hasIssue "1_Supplement" @default.
- W4313381381 hasLocation W43133813811 @default.
- W4313381381 hasOpenAccess W4313381381 @default.
- W4313381381 hasPrimaryLocation W43133813811 @default.
- W4313381381 hasRelatedWork W1564271434 @default.
- W4313381381 hasRelatedWork W2036107469 @default.
- W4313381381 hasRelatedWork W2047209980 @default.
- W4313381381 hasRelatedWork W2063167002 @default.
- W4313381381 hasRelatedWork W2081358646 @default.
- W4313381381 hasRelatedWork W2348035871 @default.
- W4313381381 hasRelatedWork W3048051248 @default.
- W4313381381 hasRelatedWork W4283731173 @default.
- W4313381381 hasRelatedWork W2396811992 @default.
- W4313381381 hasRelatedWork W2781693618 @default.
- W4313381381 hasVolume "202" @default.
- W4313381381 isParatext "false" @default.
- W4313381381 isRetracted "false" @default.
- W4313381381 workType "article" @default.