Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313381531> ?p ?o ?g. }
Showing items 1 to 66 of
66
with 100 items per page.
- W4313381531 endingPage "126.33" @default.
- W4313381531 startingPage "126.33" @default.
- W4313381531 abstract "Abstract Cutaneous immune response induced by epithelial cell stress induces represents the first line defense against pathogens. We have reported that basophils play a pivotal role in the skin inflammation caused by irritants. However, it has not been fully understood how they accumulate in the skin. Previous studies have shown that epithelial cell damage induces complement activation in organs such as the lung and the kidney, implicating a possible involvement of the complement activation in the immune response caused by epithelial cell stress in the skin. Thus, we investigated the mechanism of basophil recruitment to the skin focusing on the complement system. Topical application of the surfactant sodium dodecyl sulfate (SDS) onto murine ears induced basophil-dependent skin inflammation. Among chemokines which were up-regulated by SDS application, we found that CCL2-CCR2 axis was critical for basophil recruitment to the skin. Here, CCR2 on basophils was dispensable and CCR2 on radioresistant cells was essential. Finally, we evaluated the contribution of complement system to SDS-induced basophil recruitment to the skin. SDS application induced C3 and C5a production in the skin, suggesting a complement activation in the skin. We evaluated whether C3 and C5a are involved in SDS-induced basophil recruitment by using C3 deficient mice and C5a receptor 1 deficient mice. The result showed that C3 deficiency or C5aR1 deficiency significantly attenuated SDS-induced basophils accumulation. By contrast, SDS-induced CCL2 production in these mice was comparable to WT mice. Collectively, our data suggest that both CCL2-CCR2 and C5a-C5aR pathways are essential to the SDS-induced innate immune response in the skin by modulating basophil recruitment." @default.
- W4313381531 created "2023-01-06" @default.
- W4313381531 creator A5039640600 @default.
- W4313381531 creator A5047445074 @default.
- W4313381531 creator A5048762693 @default.
- W4313381531 date "2019-05-01" @default.
- W4313381531 modified "2023-09-23" @default.
- W4313381531 title "Essential Roles of CCL2-CCR2 and C5a-C5aR1 Pathways in irritant Contact Dermatitis" @default.
- W4313381531 doi "https://doi.org/10.4049/jimmunol.202.supp.126.33" @default.
- W4313381531 hasPublicationYear "2019" @default.
- W4313381531 type Work @default.
- W4313381531 citedByCount "0" @default.
- W4313381531 crossrefType "journal-article" @default.
- W4313381531 hasAuthorship W4313381531A5039640600 @default.
- W4313381531 hasAuthorship W4313381531A5047445074 @default.
- W4313381531 hasAuthorship W4313381531A5048762693 @default.
- W4313381531 hasConcept C101666144 @default.
- W4313381531 hasConcept C111684460 @default.
- W4313381531 hasConcept C12823836 @default.
- W4313381531 hasConcept C13373296 @default.
- W4313381531 hasConcept C141105273 @default.
- W4313381531 hasConcept C159654299 @default.
- W4313381531 hasConcept C185592680 @default.
- W4313381531 hasConcept C203014093 @default.
- W4313381531 hasConcept C206615009 @default.
- W4313381531 hasConcept C2776914184 @default.
- W4313381531 hasConcept C2777456892 @default.
- W4313381531 hasConcept C86803240 @default.
- W4313381531 hasConcept C8891405 @default.
- W4313381531 hasConcept C90582226 @default.
- W4313381531 hasConcept C95444343 @default.
- W4313381531 hasConceptScore W4313381531C101666144 @default.
- W4313381531 hasConceptScore W4313381531C111684460 @default.
- W4313381531 hasConceptScore W4313381531C12823836 @default.
- W4313381531 hasConceptScore W4313381531C13373296 @default.
- W4313381531 hasConceptScore W4313381531C141105273 @default.
- W4313381531 hasConceptScore W4313381531C159654299 @default.
- W4313381531 hasConceptScore W4313381531C185592680 @default.
- W4313381531 hasConceptScore W4313381531C203014093 @default.
- W4313381531 hasConceptScore W4313381531C206615009 @default.
- W4313381531 hasConceptScore W4313381531C2776914184 @default.
- W4313381531 hasConceptScore W4313381531C2777456892 @default.
- W4313381531 hasConceptScore W4313381531C86803240 @default.
- W4313381531 hasConceptScore W4313381531C8891405 @default.
- W4313381531 hasConceptScore W4313381531C90582226 @default.
- W4313381531 hasConceptScore W4313381531C95444343 @default.
- W4313381531 hasIssue "1_Supplement" @default.
- W4313381531 hasLocation W43133815311 @default.
- W4313381531 hasOpenAccess W4313381531 @default.
- W4313381531 hasPrimaryLocation W43133815311 @default.
- W4313381531 hasRelatedWork W1983279602 @default.
- W4313381531 hasRelatedWork W2027922456 @default.
- W4313381531 hasRelatedWork W2046776093 @default.
- W4313381531 hasRelatedWork W2059355709 @default.
- W4313381531 hasRelatedWork W2108218187 @default.
- W4313381531 hasRelatedWork W2120094575 @default.
- W4313381531 hasRelatedWork W2776126594 @default.
- W4313381531 hasRelatedWork W4232831581 @default.
- W4313381531 hasRelatedWork W4313381531 @default.
- W4313381531 hasRelatedWork W53278814 @default.
- W4313381531 hasVolume "202" @default.
- W4313381531 isParatext "false" @default.
- W4313381531 isRetracted "false" @default.
- W4313381531 workType "article" @default.