Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313381606> ?p ?o ?g. }
Showing items 1 to 66 of
66
with 100 items per page.
- W4313381606 endingPage "139.21" @default.
- W4313381606 startingPage "139.21" @default.
- W4313381606 abstract "Abstract Influenza viruses are respiratory pathogens, which cause seasonal outbreaks and result in more than 250,000 annual deaths worldwide. Vaccine inoculation is the most effective way to prevent the virus transmission. Our previous study showed that mice injected with monoglycosylated hemagglutinin (HAmg) protein vaccine designed from influenza A viruses produced cross-stain reactive antibodies and were protected better than mice injected with fully glycosylated HA (HAfg) after challenge with various influenza viruses at lethal dose. Therefore, we applied single B cell RT-PCR platform to pursue the cross-protective monoclonal antibodies (mAbs) from 2007 A (H1N1) Brisbane (Bris/07) HAmg immunized mice. A monoclonal antibody, 651, was selected, which was able to react with a broad spectrum of H1N1 viruses although it did not provide neutralizing activities. It is noted that 651 mediates antibody dependent cellular cytotoxicity (ADCC) against cells expressing HA from multiple strains of influenza viruses, including 2009 A (H1N1) swine (Cal/09), Bris/07, and H3. Alleviated weight loss and improved survival rate were observed in 651 pre-treated mice as compared with the PBS treated group after Cal/09 or Bris/07 virus infection. Interestingly, there were no protective effects against Cal/09 infection in 651 treated FcγR knockout mice. Functionally, proinflammatory cytokines accumulation in lung was ameliorated in Cal/09 infected mice pre-treated with 651. The percentage of alveolar macrophages was recovered in 651 pre-treated mice as compared with the PBS pre-treated mice after Cal/09 infection. Together, this study reveals a potent mAb that possesses broad-spectrum protective effects through the effector function of antibody." @default.
- W4313381606 created "2023-01-06" @default.
- W4313381606 creator A5008425794 @default.
- W4313381606 creator A5035427242 @default.
- W4313381606 creator A5059586912 @default.
- W4313381606 creator A5087836855 @default.
- W4313381606 creator A5089819370 @default.
- W4313381606 date "2019-05-01" @default.
- W4313381606 modified "2023-09-27" @default.
- W4313381606 title "Development of broadly neutralizing antibodies against influenza viruses from mice immunized with monoglycosylated hemagglutinin" @default.
- W4313381606 doi "https://doi.org/10.4049/jimmunol.202.supp.139.21" @default.
- W4313381606 hasPublicationYear "2019" @default.
- W4313381606 type Work @default.
- W4313381606 citedByCount "0" @default.
- W4313381606 crossrefType "journal-article" @default.
- W4313381606 hasAuthorship W4313381606A5008425794 @default.
- W4313381606 hasAuthorship W4313381606A5035427242 @default.
- W4313381606 hasAuthorship W4313381606A5059586912 @default.
- W4313381606 hasAuthorship W4313381606A5087836855 @default.
- W4313381606 hasAuthorship W4313381606A5089819370 @default.
- W4313381606 hasConcept C159047783 @default.
- W4313381606 hasConcept C159654299 @default.
- W4313381606 hasConcept C164027704 @default.
- W4313381606 hasConcept C203014093 @default.
- W4313381606 hasConcept C2522874641 @default.
- W4313381606 hasConcept C2776914184 @default.
- W4313381606 hasConcept C2777546802 @default.
- W4313381606 hasConcept C2778692840 @default.
- W4313381606 hasConcept C2779261636 @default.
- W4313381606 hasConcept C40677261 @default.
- W4313381606 hasConcept C542903549 @default.
- W4313381606 hasConcept C86803240 @default.
- W4313381606 hasConcept C89423630 @default.
- W4313381606 hasConceptScore W4313381606C159047783 @default.
- W4313381606 hasConceptScore W4313381606C159654299 @default.
- W4313381606 hasConceptScore W4313381606C164027704 @default.
- W4313381606 hasConceptScore W4313381606C203014093 @default.
- W4313381606 hasConceptScore W4313381606C2522874641 @default.
- W4313381606 hasConceptScore W4313381606C2776914184 @default.
- W4313381606 hasConceptScore W4313381606C2777546802 @default.
- W4313381606 hasConceptScore W4313381606C2778692840 @default.
- W4313381606 hasConceptScore W4313381606C2779261636 @default.
- W4313381606 hasConceptScore W4313381606C40677261 @default.
- W4313381606 hasConceptScore W4313381606C542903549 @default.
- W4313381606 hasConceptScore W4313381606C86803240 @default.
- W4313381606 hasConceptScore W4313381606C89423630 @default.
- W4313381606 hasIssue "1_Supplement" @default.
- W4313381606 hasLocation W43133816061 @default.
- W4313381606 hasOpenAccess W4313381606 @default.
- W4313381606 hasPrimaryLocation W43133816061 @default.
- W4313381606 hasRelatedWork W1843298502 @default.
- W4313381606 hasRelatedWork W1909806257 @default.
- W4313381606 hasRelatedWork W2069013632 @default.
- W4313381606 hasRelatedWork W2107100610 @default.
- W4313381606 hasRelatedWork W2140277167 @default.
- W4313381606 hasRelatedWork W2150172575 @default.
- W4313381606 hasRelatedWork W2204875792 @default.
- W4313381606 hasRelatedWork W2295375930 @default.
- W4313381606 hasRelatedWork W2992447218 @default.
- W4313381606 hasRelatedWork W1874269402 @default.
- W4313381606 hasVolume "202" @default.
- W4313381606 isParatext "false" @default.
- W4313381606 isRetracted "false" @default.
- W4313381606 workType "article" @default.