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- W4313381640 abstract "Abstract Mast cells are key players in the development of inflammatory allergic reactions. Cross-linking of the high-affinity receptor for IgE (FcɛRI) on mast cells leads to the generation and secretion of the sphingolipid mediator, sphingosine-1-phosphate (S1P) which can in turn activate its G-protein coupled receptors on mast cells. Previous reports have identified the expression of two of the five receptors for S1P on mast cells, S1P1 and S1P2, with functions in IgE-receptor-mediated chemotaxis and degranulation, respectively. Here, we show that cultured human and mouse mast cells also express abundant message for the S1P4 receptor and demonstrate its presence at the plasma membrane in the human mast cell line LAD2. Genetic deletion of S1pr4 resulted in exacerbation of passive systemic anaphylaxis to IgE/anti-IgE in mice. However, exhaustive characterization of IgE-mediated responses in S1P4-deficient bone marrow and peritoneal mouse mast cells indicated that this receptor is dispensable for normal in vitro mast cell growth and responses to IgE-mediated activation including degranulation, cytokine/chemokine release and chemotaxis. Thus, we provide evidence that S1P4 modulates mast cell-mediated anaphylaxis in vivo in an unexpected manner that does not involve regulation of mast cell responsiveness to IgE stimulation." @default.
- W4313381640 created "2023-01-06" @default.
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- W4313381640 date "2018-05-01" @default.
- W4313381640 modified "2023-09-27" @default.
- W4313381640 title "Sphingosine-1-phospate receptor 4 regulates passive systemic anaphylaxis in mice but is dispensable for canonical IgE-mediated responses in mast cells" @default.
- W4313381640 doi "https://doi.org/10.4049/jimmunol.200.supp.105.1" @default.
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