Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313381851> ?p ?o ?g. }
Showing items 1 to 66 of
66
with 100 items per page.
- W4313381851 endingPage "173.14" @default.
- W4313381851 startingPage "173.14" @default.
- W4313381851 abstract "Abstract Defective mucociliary clearance (MCC) associated with muco-obstructive lung diseases may compromise effective clearance of aspirated bacteria. Mucus hypersecretion is often associated with mucous cell metaplasia (MCM) of airway epithelium, which is a Type 2 immune response. Whether ablation of Type 2 response abolishes MCM/muco-obstruction, and thus, enhances bacterial clearance remains untested. Accordingly, we hypothesized that the ablation of adaptive immune responses will promote bacterial clearance in murine model of defective MCC, i.e., Scnn1b [Sodium channel, non-voltage-gated 1, beta] transgenic (Tg+) mice. The Tg+ model recapitulates hallmarks of muco-obstructive airways, including MCM and bacterial infections. The Type 2 response deficient (Il2rg−/−, Rag1−/− and Il2rg −/−Rag1−/−) mice strains on Tg+ background were observed at neonatal age (6–7 days) for bacterial clearance response. Our data suggest that while Il2rg−/− mice [lacking innate lymphoid cells (ILC)] had significantly impaired bacterial clearance in control (Tg−) as well as Tg+, the Rag1−/−mice [lacking adaptive immune response] did not exhibit impaired bacterial clearance in Tg− as well as Tg+ neonates. The defective bacterial clearance in Il2rg−/− was not due to reduced phagocyte recruitment. Interestingly, Il2rg −/−Rag1−/− mice had significantly improved bacterial clearance, an observation that remains a focus of our ongoing investigation. Our analyses revealed absence of IL-10 in Rag1−/−mice was associated with morphological activation of macrophages. Taken together, our current data suggest that while ILCs are essential for bacterial clearance, the adaptive immune responses suppress macrophage’s antibacterial function." @default.
- W4313381851 created "2023-01-06" @default.
- W4313381851 creator A5019746587 @default.
- W4313381851 creator A5045723928 @default.
- W4313381851 creator A5047516329 @default.
- W4313381851 date "2018-05-01" @default.
- W4313381851 modified "2023-09-27" @default.
- W4313381851 title "Ablation of adaptive immune responses facilitates increased bacterial clearance in murine model of defective mucociliary clearance" @default.
- W4313381851 doi "https://doi.org/10.4049/jimmunol.200.supp.173.14" @default.
- W4313381851 hasPublicationYear "2018" @default.
- W4313381851 type Work @default.
- W4313381851 citedByCount "0" @default.
- W4313381851 crossrefType "journal-article" @default.
- W4313381851 hasAuthorship W4313381851A5019746587 @default.
- W4313381851 hasAuthorship W4313381851A5045723928 @default.
- W4313381851 hasAuthorship W4313381851A5047516329 @default.
- W4313381851 hasConcept C114682108 @default.
- W4313381851 hasConcept C126322002 @default.
- W4313381851 hasConcept C160448771 @default.
- W4313381851 hasConcept C193419808 @default.
- W4313381851 hasConcept C203014093 @default.
- W4313381851 hasConcept C2522874641 @default.
- W4313381851 hasConcept C2777714996 @default.
- W4313381851 hasConcept C2778821649 @default.
- W4313381851 hasConcept C2779341262 @default.
- W4313381851 hasConcept C534529494 @default.
- W4313381851 hasConcept C71924100 @default.
- W4313381851 hasConcept C86803240 @default.
- W4313381851 hasConcept C87568996 @default.
- W4313381851 hasConcept C8891405 @default.
- W4313381851 hasConcept C89423630 @default.
- W4313381851 hasConceptScore W4313381851C114682108 @default.
- W4313381851 hasConceptScore W4313381851C126322002 @default.
- W4313381851 hasConceptScore W4313381851C160448771 @default.
- W4313381851 hasConceptScore W4313381851C193419808 @default.
- W4313381851 hasConceptScore W4313381851C203014093 @default.
- W4313381851 hasConceptScore W4313381851C2522874641 @default.
- W4313381851 hasConceptScore W4313381851C2777714996 @default.
- W4313381851 hasConceptScore W4313381851C2778821649 @default.
- W4313381851 hasConceptScore W4313381851C2779341262 @default.
- W4313381851 hasConceptScore W4313381851C534529494 @default.
- W4313381851 hasConceptScore W4313381851C71924100 @default.
- W4313381851 hasConceptScore W4313381851C86803240 @default.
- W4313381851 hasConceptScore W4313381851C87568996 @default.
- W4313381851 hasConceptScore W4313381851C8891405 @default.
- W4313381851 hasConceptScore W4313381851C89423630 @default.
- W4313381851 hasIssue "1_Supplement" @default.
- W4313381851 hasLocation W43133818511 @default.
- W4313381851 hasOpenAccess W4313381851 @default.
- W4313381851 hasPrimaryLocation W43133818511 @default.
- W4313381851 hasRelatedWork W2090477263 @default.
- W4313381851 hasRelatedWork W2103515427 @default.
- W4313381851 hasRelatedWork W2191084826 @default.
- W4313381851 hasRelatedWork W2223869382 @default.
- W4313381851 hasRelatedWork W2766647135 @default.
- W4313381851 hasRelatedWork W2810380358 @default.
- W4313381851 hasRelatedWork W2938430682 @default.
- W4313381851 hasRelatedWork W2947413141 @default.
- W4313381851 hasRelatedWork W3123216987 @default.
- W4313381851 hasRelatedWork W573847062 @default.
- W4313381851 hasVolume "200" @default.
- W4313381851 isParatext "false" @default.
- W4313381851 isRetracted "false" @default.
- W4313381851 workType "article" @default.