Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313382009> ?p ?o ?g. }
Showing items 1 to 66 of
66
with 100 items per page.
- W4313382009 endingPage "220.20" @default.
- W4313382009 startingPage "220.20" @default.
- W4313382009 abstract "Abstract Tregs and Th17 cells have a very close and complex relationship. Tregs and Th17 cells share a dependence on TGFb for their differentiation and it has recently been shown that Tregs require the Th17-driving transcription factor STAT3 to regulate Th17 responses. Despite sharing a dependence on STAT3, Tregs within healthy tissue tend to produce very low amounts of IL-17. In contrast, in multiple Th17-driven diseases (including Multiple Sclerosis, Psoriasis and Crohn’s) Tregs within the diseased tissue produce increased levels of the IL-17. The costimulatory receptor CD27 and its ligand, CD70, have been shown to play a role in suppressing Th17 responses through the epigenetic suppression of IL-17 and CCR6. We have found that CD27 is highly expressed on Tregs in both human and murine skin, but whether CD27 plays a role in promoting Treg function (and suppressing acquisition of Th17-like traits) remains unknown. Utilizing CD27-deficient mice (CD27KO), we found that Tregs in the skin of CD27KO mice in the steady state produced more IL-17 compared to their wild-type (WT) counterparts. To test the role of CD27 specifically on Tregs during Th17-driven inflammation in vivo, we have developed an adoptive transfer model of cutaneous candida albicans infection where Tregs play an essential role in the development of productive Th17 responses. Using this model, we found that CD27 suppressed Treg expression of IL-17 and CCR6 in a cell-intrinsic manner. We also found that IL-6 could induce the production of IL-17 from Tregs in vitro which was suppressed when co-cultured with CD70 expressing BMDCs. Our studies suggest that the CD27-CD70 pathway promotes Treg function by limiting production of Th17 effector molecules." @default.
- W4313382009 created "2023-01-06" @default.
- W4313382009 creator A5012143724 @default.
- W4313382009 creator A5053096281 @default.
- W4313382009 creator A5068872667 @default.
- W4313382009 date "2017-05-01" @default.
- W4313382009 modified "2023-09-28" @default.
- W4313382009 title "Elucidating the Role of CD27 in Treg Function during Th17 Responses" @default.
- W4313382009 doi "https://doi.org/10.4049/jimmunol.198.supp.220.20" @default.
- W4313382009 hasPublicationYear "2017" @default.
- W4313382009 type Work @default.
- W4313382009 citedByCount "0" @default.
- W4313382009 crossrefType "journal-article" @default.
- W4313382009 hasAuthorship W4313382009A5012143724 @default.
- W4313382009 hasAuthorship W4313382009A5053096281 @default.
- W4313382009 hasAuthorship W4313382009A5068872667 @default.
- W4313382009 hasConcept C12823836 @default.
- W4313382009 hasConcept C13373296 @default.
- W4313382009 hasConcept C203014093 @default.
- W4313382009 hasConcept C2776090121 @default.
- W4313382009 hasConcept C2776914184 @default.
- W4313382009 hasConcept C2778923194 @default.
- W4313382009 hasConcept C2779727006 @default.
- W4313382009 hasConcept C47348012 @default.
- W4313382009 hasConcept C62478195 @default.
- W4313382009 hasConcept C74737994 @default.
- W4313382009 hasConcept C86803240 @default.
- W4313382009 hasConcept C8891405 @default.
- W4313382009 hasConcept C90375314 @default.
- W4313382009 hasConcept C94205230 @default.
- W4313382009 hasConcept C95444343 @default.
- W4313382009 hasConceptScore W4313382009C12823836 @default.
- W4313382009 hasConceptScore W4313382009C13373296 @default.
- W4313382009 hasConceptScore W4313382009C203014093 @default.
- W4313382009 hasConceptScore W4313382009C2776090121 @default.
- W4313382009 hasConceptScore W4313382009C2776914184 @default.
- W4313382009 hasConceptScore W4313382009C2778923194 @default.
- W4313382009 hasConceptScore W4313382009C2779727006 @default.
- W4313382009 hasConceptScore W4313382009C47348012 @default.
- W4313382009 hasConceptScore W4313382009C62478195 @default.
- W4313382009 hasConceptScore W4313382009C74737994 @default.
- W4313382009 hasConceptScore W4313382009C86803240 @default.
- W4313382009 hasConceptScore W4313382009C8891405 @default.
- W4313382009 hasConceptScore W4313382009C90375314 @default.
- W4313382009 hasConceptScore W4313382009C94205230 @default.
- W4313382009 hasConceptScore W4313382009C95444343 @default.
- W4313382009 hasIssue "1_Supplement" @default.
- W4313382009 hasLocation W43133820091 @default.
- W4313382009 hasOpenAccess W4313382009 @default.
- W4313382009 hasPrimaryLocation W43133820091 @default.
- W4313382009 hasRelatedWork W1535737655 @default.
- W4313382009 hasRelatedWork W1963482184 @default.
- W4313382009 hasRelatedWork W2103760280 @default.
- W4313382009 hasRelatedWork W2115301098 @default.
- W4313382009 hasRelatedWork W2119582157 @default.
- W4313382009 hasRelatedWork W2808189998 @default.
- W4313382009 hasRelatedWork W3203980559 @default.
- W4313382009 hasRelatedWork W4293032553 @default.
- W4313382009 hasRelatedWork W4313359246 @default.
- W4313382009 hasRelatedWork W4313382009 @default.
- W4313382009 hasVolume "198" @default.
- W4313382009 isParatext "false" @default.
- W4313382009 isRetracted "false" @default.
- W4313382009 workType "article" @default.