Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313382016> ?p ?o ?g. }
Showing items 1 to 52 of
52
with 100 items per page.
- W4313382016 endingPage "147.2" @default.
- W4313382016 startingPage "147.2" @default.
- W4313382016 abstract "Abstract Vaccination remains the most effective public health tool to prevent infectious disease. Many vaccines are marginally effective, and are less so when administered to immune-compromised populations. To enhance vaccine immunogenicity, we exploited the biphasic property of the (RADA)4 synthetic oligopeptide to create a new vaccine delivery method, VacSIM® (vaccine self-assembling immune matrix). Vaccine components are mixed with the VacSIM® solution for injection, after which the (RADA)4 peptides self-assemble into hydrated nanofiber gel-matrices, forming a vaccine depot with the vaccine antigens in the aqueous phase, allowing for slow-release of vaccine components over time. Thus, we have a non-viral, inert, biodegradable delivery system, not requiring formulation that can deliver various types of vaccines. We hypothesize that slow-release of vaccine components provides antigen persistence, driving enhanced vaccine-specific responses that are improved in both quantity and quality. We have tested VacSIM® with live bacterial vectors, inactivated virus and multiple recombinant protein vaccines. VacSIM® delivery of different protein immunogens, including Hepatitis B and HIV Envelope, is superior to delivery in licensed and unlicensed adjuvants and requires only a single injection. VacSIM® improves existing vaccines by reducing the number of injections needed, improving vaccine performance, especially in difficult-to-protect populations like the elderly and immune compromised, and reducing unwelcome side effects. VacSIM® can be stockpiled and stored without a cold chain, which is especially beneficial in resource-limited settings where vaccine access and compliance are issues." @default.
- W4313382016 created "2023-01-06" @default.
- W4313382016 creator A5001831036 @default.
- W4313382016 creator A5060017067 @default.
- W4313382016 date "2017-05-01" @default.
- W4313382016 modified "2023-09-27" @default.
- W4313382016 title "Vaccine self-assembling immune matrix is a non-viral delivery platform that improves overall vaccine performance while maintaining safety and stability" @default.
- W4313382016 doi "https://doi.org/10.4049/jimmunol.198.supp.147.2" @default.
- W4313382016 hasPublicationYear "2017" @default.
- W4313382016 type Work @default.
- W4313382016 citedByCount "0" @default.
- W4313382016 crossrefType "journal-article" @default.
- W4313382016 hasAuthorship W4313382016A5001831036 @default.
- W4313382016 hasAuthorship W4313382016A5060017067 @default.
- W4313382016 hasConcept C147483822 @default.
- W4313382016 hasConcept C159047783 @default.
- W4313382016 hasConcept C203014093 @default.
- W4313382016 hasConcept C22070199 @default.
- W4313382016 hasConcept C2777863537 @default.
- W4313382016 hasConcept C2780441014 @default.
- W4313382016 hasConcept C2780868878 @default.
- W4313382016 hasConcept C71924100 @default.
- W4313382016 hasConcept C8891405 @default.
- W4313382016 hasConceptScore W4313382016C147483822 @default.
- W4313382016 hasConceptScore W4313382016C159047783 @default.
- W4313382016 hasConceptScore W4313382016C203014093 @default.
- W4313382016 hasConceptScore W4313382016C22070199 @default.
- W4313382016 hasConceptScore W4313382016C2777863537 @default.
- W4313382016 hasConceptScore W4313382016C2780441014 @default.
- W4313382016 hasConceptScore W4313382016C2780868878 @default.
- W4313382016 hasConceptScore W4313382016C71924100 @default.
- W4313382016 hasConceptScore W4313382016C8891405 @default.
- W4313382016 hasIssue "1_Supplement" @default.
- W4313382016 hasLocation W43133820161 @default.
- W4313382016 hasOpenAccess W4313382016 @default.
- W4313382016 hasPrimaryLocation W43133820161 @default.
- W4313382016 hasRelatedWork W1481917790 @default.
- W4313382016 hasRelatedWork W2009090497 @default.
- W4313382016 hasRelatedWork W2090698640 @default.
- W4313382016 hasRelatedWork W2095304551 @default.
- W4313382016 hasRelatedWork W2289160872 @default.
- W4313382016 hasRelatedWork W2376546987 @default.
- W4313382016 hasRelatedWork W2411712784 @default.
- W4313382016 hasRelatedWork W2466910529 @default.
- W4313382016 hasRelatedWork W3109192410 @default.
- W4313382016 hasRelatedWork W4323569182 @default.
- W4313382016 hasVolume "198" @default.
- W4313382016 isParatext "false" @default.
- W4313382016 isRetracted "false" @default.
- W4313382016 workType "article" @default.